Kainate lesion dissociates striatal dopamine receptor radioligand binding sites.
Kainate lesion dissociates striatal dopamine receptor radioligand binding sites.
复制标题
红藻氨酸损伤使纹状体多巴胺受体放射性配体结合位点解离。
DOI：
10.1016/0014-2999(81)90434-9
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发表时间：
1981
影响因子：
5
通讯作者：
Creese,I
中科院分区：
文献类型：
--
作者：
Leff,S;Adams,L;Hyttel,J;Creese,I
Kainic acid lesion of rat striata reduces the specific dopamine receptor binding of the butyrophenone antagonist [3H]spiperone and the butyrophenone-like antagonist [3H]domperidone by 56% and 59% respectively. Significantly greater decreases in binding were observed with the agonist [3H]N-propylnorapomorphine (NPA) and the antagonist [3H]flupentixol which showed 79% and 73% losses of high affinity binding respectively. These data indicate that, in part, [3H]spiperone and [3H]domperidone label distinct dopamine receptors with different neuronal localizations from the those labeled by [3H]flupentixol and [3H]NPA. Our data is consistent with the hypothesis that [3H]flupentixol and [3H]NPA bind preferentially to adenylate cyclase-linked dopamine (D1) receptors.
