TREATMENT OF FISH PARASITES .1. PRAZIQUANTEL EFFECTIVE AGAINST MONOGENEA (DACTYLOGYRUS-VASTATOR, DACTYLOGYRUS-EXTENSUS, DIPLOZOON-PARADOXUM)
TREATMENT OF FISH PARASITES .1. PRAZIQUANTEL EFFECTIVE AGAINST MONOGENEA (DACTYLOGYRUS-VASTATOR, DACTYLOGYRUS-EXTENSUS, DIPLOZOON-PARADOXUM)
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DOI：
10.1007/bf00926798
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发表时间：
1985-01-01
期刊：
影响因子：
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通讯作者：
MEHLHORN, H
中科院分区：
文献类型：
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作者：
SCHMAHL, G;MEHLHORN, H
实验结果表明，吡喹酮对塘养鲤鱼鳃寄生的单属蝇（vasttylogyrus, Dactylogyrus extensus）有较好的防治效果。此外，还研究了吡喹酮对头角鲨（Squalius cephalus）的拮抗作用。分别在22℃下孵育30、60、90、120或180 min。C在水中的含量为0（对照）、1、5、10、100 μ。g吡喹酮/毫升。结果表明，该药物在暴露于至少1 μ m后30 min内可引起单属植物被膜的不可逆改变。g吡喹酮/毫升。在体外发现的损伤导致寄生虫的被皮空泡化。3种被被交替的程度差异不大：掌趾龙被被在全身各部位均有空泡化，其中在剑爪部和足柄区尤甚。即使用吡喹酮杀死寄生虫，也不会从鳃上掉下来。在大趾突中，尤以截爪区受累。蠕虫通常会失去边缘钩和大钩。与伸展趾虫不同，经处理的蠕虫经常从鳃上掉下来。矛盾双虫对该药的敏感性较低。孵育后1亩。G吡喹酮/ml给药7 h，虫体运动能力下降。剂量为10亩。G /ml和150 .mu。G /ml持续1.5 h导致被皮严重损伤，尤其是口腔吸盘区域。然而，这种药物对治疗这种寄生虫是有效的。建议用吡喹酮10 mg /l， 22℃，持续治疗3 h，可有效地防治扩张趾螨和伸展趾螨。C在较小的储罐中储存。
In several experiments it was shown that praziquantal is effective against Monogenea (Dactylogyrus vastator, Dactylogyrus extensus) parasitizing the gills of pond-reared carp (Cyprinus carpio). Also, the effects of praziquantel on Diplozoon paradoxum from chub (Squalius cephalus) were investigated. Infested carp were incubated for 30, 60, 90, 120 or 180 min at 22.degree. C in water containing 0 (control), 1, 5, 10, 100 .mu.g praziquantel/ml. It was found that the drug caused irreversible alterations in the tegument of Monogenea within 30 min after exposure to at least 1 .mu.g praziquantel/ml. The damage found in vitro resulted in vacuolisation of the parasites'' teguments. The three species showed little differences in the grade of tegumental alternation: Dactylogyrus vastator showed vacuolisation of its tegument in all regions of its body, which was very marked in the opisthaptor and in the peduncle region. Parasites did not drop from the gill even when killed by treatment with praziquantel. In Dactylogyrus extensus the opisthaptor region was especially affected. The worms usually lost their marginal hooklets as well as the large hooks. In contrast to Dactylogyrus vastator, treated worms often dropped from gills. Diplozoon paradoxum was lesser sensitive to the drug. After incubation in 1 .mu.g praziquantel/ml for 7 h the worms had a reduced motility. Doses of 10 .mu.g/ml and 150 .mu.g/ml for 1.5 h led to severe damage of the tegument, especially in the region of the oral sucker. However, the drug is effective in treatment of this parasite. It is suggested that therapy against Dactylogyrus vastator and Dactylogyrus extensus in carp fingerlings may be done with 10 mg praziquantel/l for 3 h at 22.degree. C during storage in smaller tanks.