Fibroblast Growth Factor 2 and Its Receptors in Bone Biology and Disease.
Fibroblast Growth Factor 2 and Its Receptors in Bone Biology and Disease.
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DOI：
10.1210/js.2018-00105
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发表时间：
2018-07-01
影响因子：
4.1
通讯作者：
Hurley MM
中科院分区：
文献类型：
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作者：
Coffin JD;Homer-Bouthiette C;Hurley MM
成纤维细胞生长因子（FGF）调节轴在遗传学上是古老的，进化成22个配体的大型哺乳动物/人类基因家族，其结合四种受体酪氨酸激酶用于控制细胞生长、分化和代谢的复杂生理系统。主要FGF功能的组织靶点主要在软骨和骨中用于形态发生、矿化和代谢。FGF配体-受体信号传导途径中的许多复杂性使得转化为FGF相关骨疾病（如骨软化症、骨关节炎和骨质疏松症）的疗法变得困难但并非不可能。本文综述了FGF 2及其受体在骨生物学和疾病中的作用，重点是我们目前的理解，知识的差距和未来的研究是必要的。
The fibroblast growth factor (FGF) regulatory axis is phylogenetically ancient, evolving into a large mammalian/human gene family of 22 ligands that bind to four receptor tyrosine kinases for a complex physiologic system controlling cell growth, differentiation, and metabolism. The tissue targets for the primary FGF function are mainly in cartilage and in bone for morphogenesis, mineralization, and metabolism. A multitude of complexities in the FGF ligand-receptor signaling pathways have made translation into therapies for FGF-related bone disorders such as osteomalacia, osteoarthritis, and osteoporosis difficult but not impossible. The article reviews the role of FGF2 and its receptors in bone biology and disease, focusing on our current understanding, gaps in knowledge, and future studies that are needed.