Consumption of vegetables alters morning urinary 6-sulfatoxymelatonin concentration
Consumption of vegetables alters morning urinary 6-sulfatoxymelatonin concentration
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DOI：
10.1111/j.1600-079x.2007.00549.x
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发表时间：
2008-08-01
影响因子：
10.3
通讯作者：
Nagata, Chisato
中科院分区：
文献类型：
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作者：
Oba, Shino;Nakamura, Kozue;Nagata, Chisato
某些蔬菜中含有的褪黑素可能会对循环中的褪黑素浓度产生影响。本研究旨在探讨进食蔬菜对晨尿中6-硫氧基黑蛋白浓度的影响。日本一家城市公共卫生中心招募了94名年龄在24-55岁的健康女性。随机分配到干预组的女性被要求摄入高剂量的6种蔬菜，目标是每天350g，持续65天，而对照组被要求在同一时期避免食用同样的6种蔬菜。在干预期结束前和结束时收集首次排空的晨尿，并测定肌酐调节的6-硫代氧肌红素浓度。干预结束时，干预组6种蔬菜的褪黑素平均日摄入量为1288.0 ng，对照组为5.3ng。在干预组中，6-硫氧基黑素的平均浓度从48.1[95%可信区间：40.4~57.2]ng/mg肌酐变化到49.6(95%可信区间：42.8~57.3)ng/mg肌酐。对照组在干预期内6-硫氧基肌醇平均浓度由55.5(95%可信区间：48.7~63.2)ng/mg肌酐降至50.8(95%可信区间：44.0~58.7)ng/mg肌酐。干预期内两组间6-硫代氧肌松浓度变化比较，差异有统计学意义(P=0.03)。结果表明，蔬菜消费量的增加会增加循环中褪黑素的浓度。
Melatonin, which is contained in certain vegetables, may have an influence on circulatory melatonin concentrations. This study examined the effects of the consumption of vegetables on 6-sulfatoxymelatonin concentrations in morning urine. Ninety-four healthy women aged 24-55 were recruited through a city public health center in Japan. The women randomly allocated to the intervention group were requested to consume high amounts of six selected vegetables, with a target of 350 g/day for 65 days, while those in the control group were asked to avoid the same six vegetables during the same period. First-void morning urine was collected before and at the end of the intervention period, and creatinine-adjusted 6-sulfatoxymelatonin concentrations were measured. At the end of the intervention period, daily mean intake of melatonin from the six vegetables was 1288.0 ng in the intervention group and 5.3 ng in the control group. In the intervention group, the mean concentration of 6-sulfatoxymelatonin changed from 48.1 [95% confidence interval (CI): 40.4-57.2] ng/mg creatinine to 49.6 (95% CI: 42.8-57.3) ng/mg creatinine across the intervention period. In the control group, the mean concentration of 6-sulfatoxymelatonin changed from 55.5 (95% CI: 48.7-63.2) ng/mg creatinine to 50.8 (95% CI: 44.0-58.7) ng/mg creatinine across the intervention period. A comparison of the two groups with regard to the changes in the 6-sulfatoxymelatonin concentrations across the intervention period showed a significant difference (P = 0.03). The results indicate that increased consumption of vegetables raises circulatory melatonin concentrations.