Early development of human hematopoietic and acquired immune systems in new born NOD/Scid/Jak3null mice intrahepatic engrafted with cord blood-derived CD34+ cells
Early development of human hematopoietic and acquired immune systems in new born NOD/Scid/Jak3null mice intrahepatic engrafted with cord blood-derived CD34+ cells
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DOI：
10.1007/s12185-008-0215-z
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发表时间：
2008-12-01
影响因子：
2.1
通讯作者：
Suzu, Shinya
中科院分区：
文献类型：
--
作者：
Okada, Seiji;Harada, Hideki;Suzu, Shinya
在体内研究获得性免疫时，需要一种能够重建人体免疫系统的动物模型。我们在这里报告了一种新的模型，NOD/SCID/JAK 3（null）小鼠，用于人类免疫系统的发展。新生小鼠肝内移植人脐带血CD 34（+）细胞，产生人T和B细胞，以及髓样和浆细胞样树突状细胞。T和B细胞具有幼稚记忆表型，并且包括浆细胞。人获得性免疫系统可以从NOD/SCID/JAK 3（null）小鼠中的CD 34（+）细胞重建。该模型是研究人体免疫功能的有力工具。
An animal model in which the human immune system can be reconstituted is necessary to study acquired immunity in vivo. We report here a novel model, the NOD/SCID/JAK3(null) mouse, for the human immune system's development. Newborn mice transplanted with human cord blood CD34(+) cells intrahepatically, developed human T and B cells, and myeloid and plasmacytoid dendritic cells. The T and B cells had a naive to memory phenotype, and included plasma cells. The human acquired immune system can be reconstituted from CD34(+) cells in NOD/SCID/JAK3(null) mice. This model is a powerful tool for the study of human immunity.