DESIGN PRINCIPLES OF VASCULAR BEDS
DESIGN PRINCIPLES OF VASCULAR BEDS
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DOI：
10.1161/01.res.77.5.1017
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发表时间：
1995-11-01
影响因子：
20.1
通讯作者：
GAEHTGENS, P
中科院分区：
文献类型：
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作者：
PRIES, AR;SECOMB, TW;GAEHTGENS, P
采用实验测量和理论模拟相结合的方法，测定了大鼠肠系膜6个完整微血管网中每个血管段的血流动力学参数。对于总数为2592节段，一个强大的统一的壁面切应力依赖于血管内压力的小动脉，毛细血管和小静脉。当血管内压力从70 mm Hg福尔斯到15 mm Hg时，所有三种类型的节段表现出从高到低值（从大约100到10 dyne/cm（2））的剪应力变化基本相同。基于这些观察，有人提出，血管床的生长和适应，以保持在每个血管中的剪切应力的水平，取决于当地的跨壁压。与Murray的经典“最小成本”假设（意味着整个血管系统的壁剪切率均匀）相反，拟议的设计原则为循环中壁剪切率和流动阻力的功能重要的动静脉不对称性提供了解释。
Hemodynamic parameters were determined in each vessel segment of six complete microvascular networks in the rat mesentery by using a combination of experimental measurements and theoretical simulations. For a total number of 2592 segments, a strong unified dependence of wall shear stress on intravascular pressure for arterioles, capillaries, and venules was obtained. All three types of segments exhibit an essentially identical variation of shear stress from high to low values (from approximate to 100 to 10 dyne/cm(2)) as intravascular pressure falls from 70 to 15 mm Hg. On the basis of these observations, it is proposed that vascular beds grow and adapt so as to maintain the shear stress in each vessel at a level that depends on local transmural pressure. In contrast to Murray's classic 'minimum-cost' hypothesis, which implies uniformity of wall shear rate throughout the vasculature, the proposed design principle provides an explanation for the functionally important arteriovenous asymmetry of wall shear rates and flow resistance in the circulation.