Fatal intoxication with 3-methyl-N-methylcathinone (3-MMC) and 5-(2-aminopropyl)benzofuran (5-APB)
Fatal intoxication with 3-methyl-N-methylcathinone (3-MMC) and 5-(2-aminopropyl)benzofuran (5-APB)
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DOI：
10.1016/j.forsciint.2014.10.016
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发表时间：
2014-12-01
影响因子：
2.2
通讯作者：
Byrska, Bogumila
中科院分区：
文献类型：
--
作者：
Adamowicz, Piotr;Zuba, Dariusz;Byrska, Bogumila
近年来大量新精神活性物质的出现给临床和法医毒理学工作者带来了严重的问题。在这里，我们报告一个病人谁管理CA。500 mg 3-MMC（3-甲基-N-甲基卡西酮）和400 mg 5-APB（5-（2-氨基丙基）苯并呋喃）与80 g乙醇的组合。临床表现包括激越、惊厥、高血压、心动过速、高热和心动过缓。患者未痊愈，用药后约4小时死亡。死亡原因是NPS和酒精混合中毒后发生的急性心血管衰竭。尸检血液的毒理学分析显示3-MMC和5-APB的浓度分别为1.6 μ g/mL和5.6 μ g/mL。此外，在入院后1小时收集的死前样本中，血清酒精浓度为1.4 g/L。本文首次报道了3-MMC和5-APB在急性中毒中的血药浓度。(C)2014爱思唯尔爱尔兰有限公司版权所有。
The emergence of a large number of new psychoactive substances (NPSs) in recent years poses a serious problem to clinical and forensic toxicologists. Here we report a patient who administrated ca. 500 mg of 3-MMC (3-methyl-N-methylcathinone) and 400 mg of 5-APB (5-(2-aminopropyl)benzofuran) in combination with 80 g of ethyl alcohol. The clinical manifestations included agitation, seizures, hypertension, tachycardia, hyperthermia and bradycardia. The patient did not recover and died around 4 h after the use of drugs. The cause of death was acute cardiovascular collapse that occurred following mixed intoxication with NPSs and alcohol. Toxicological analysis of post-mortem blood revealed 3-MMC and 5-APB in concentrations of 1.6 mu g/mL and 5.6 mu g/mL, respectively. Moreover, the serum alcohol concentration was 1.4 g/L in ante-mortem sample collected 1 h after admission to the hospital. This is the first report on blood concentration of 3-MMC and 5-APB in fatal intoxication. (C) 2014 Elsevier Ireland Ltd. All rights reserved.