Adiponectin: serum levels, promoter polymorphism, and associations with birth size and cardiometabolic outcome in young adults born large for gestational age
Adiponectin: serum levels, promoter polymorphism, and associations with birth size and cardiometabolic outcome in young adults born large for gestational age
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DOI：
10.1530/eje-09-0697
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发表时间：
2010-01-01
影响因子：
5.8
通讯作者：
Antonini, Sonir R.
中科院分区：
文献类型：
--
作者：
Bueno, Ana Carolina;Espineira, Aniette R.;Antonini, Sonir R.
目的：评估脂联素基因调控区（ADIPOQ）-11391G > A多态性是否与出生体重、出生后生长、脂联素血症和成年期心脏代谢风险相关。设计：病例对照研究，纳入一个前瞻性队列，队列中有2063名出生于1978/1979年的社区受试者，并从出生至今进行随访。ADIPOQ-11391 G> A基因型-表型关联在116名出生时大于胎龄（LGA）的受试者和392名出生时性别匹配的对照者中进行了评估。（出生体重），8-10岁（追赶式增长），23-25岁结果：LGA患者-11391A变异等位基因频率较高（P=0.04）。AA基因型与LGA出生概率增加相关（比值比=4.14; 95%可信区间：1.16-16.7; P=0.03）。这种多态性既不与身体成分，也不与出生后的生长模式。在23-25岁年龄段，-11391A变异等位基因与较高的血清脂联素水平相关（GG：10.7 +/- 6.2 vs GA：12.2 +/- 6.5 vs AA：14.2 +/- 6.8 μ g/ml; P < 0.01）。LGA出生的受试者的体重指数（BMI; P=0.01）、腹围（P=0.04）、血压（P= 0.04）和胰岛素抵抗稳态评估模型（P=0.01）均高于适合胎龄的受试者。出生时的对称性对这些变量没有影响。结论：ADIPOQ基因-11391A变异与LGA的发生率增加和成年早期脂联素水平升高有关。
Objective: To assess whether the -11391G > A polymorphism in the regulatory region of the adiponectin gene (ADIPOQ) is associated with birth size, postnatal growth, adiponectinemia, and cardiometabolic risk in adult life.Design: Case-control study nested within a prospective cohort of 2063 community subjects born in 1978/1979 and followed since birth to date.Methods: ADIPOQ -11391G > A genotype-phenotype associations were evaluated in 116 subjects born large for gestational age (LGA) and 392 gender-matched controls at birth (birth size), at 8-10 years (catch-down growth), and at 23-25 years of age (cardiometabolic profile).Results: The -11391A variant allele frequency was higher in LGA subjects (P=0.04). AA genotype was associated with augmented probability of being born LGA (odds ratio=4.14; 95% confidence interval: 1.16-16.7; P=0.03). This polymorphism was associated neither with body composition nor with postnatal growth pattern. At the age of 23-25 years, the -11391A variant allele was associated with higher serum adiponectin levels (GG: 10.7 +/- 6.2 versus GA: 12.2 +/- 6.5 versus AA: 14.2 +/- 6.8 mu g/ml; P < 0.01). Subjects born LGA presented higher body mass index (BMI; P=0.01), abdominal circumference (P=0.04), blood pressure (P=0.04), and homeostasis assessment model for insulin resistance (P=0.01) than adequate for gestational age. Symmetry at birth did not influence these variables. The occurrence of catch-down of weight was associated with lower BMI and abdominal circumference (P < 0.001) at 23-25 years.Conclusions: The -11391A ADIPOQ gene variant was associated with increased chance of being born LGA and with higher adiponectin levels in early adult life.