Platycodon grandiflorus polysaccharide regulates colonic immunity through mesenteric lymphatic circulation to attenuate ulcerative colitis
Platycodon grandiflorus polysaccharide regulates colonic immunity through mesenteric lymphatic circulation to attenuate ulcerative colitis
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桔梗多糖通过肠系膜淋巴循环调节结肠免疫，减轻溃疡性结肠炎
DOI：
10.1016/s1875-5364(23)60435-2
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发表时间：
2023-04-27
影响因子：
4.6
通讯作者：
Yin, Dengke
中科院分区：
文献类型：
--
作者：
Liu, Yang;Dong, Yahui;Yin, Dengke
桔梗多糖（Platycodongrandifloruspolysaccharide，PGP）是桔梗中的主要成分之一，但其抗炎作用机制尚未完全阐明。本研究旨在评价PGP对右旋糖酐硫酸钠（DSS）诱导的小鼠溃疡性结肠炎（UC）的治疗作用并探讨其作用机制。结果表明，PGP治疗抑制DSS诱导的UC小鼠的体重下降，增加结肠长度，减少DAI，脾指数和结肠内的病理损伤。PGP还能降低促炎细胞因子的水平，抑制氧化应激和MPO活性的增强。同时，PGP还能恢复结肠内Th1、Th2、Th17和Treg细胞相关的细胞因子和转录因子水平，调节结肠免疫功能。进一步的研究表明，PGP通过肠系膜淋巴循环调节结肠免疫细胞的平衡。PGP通过肠系膜淋巴循环发挥抗炎和抗氧化作用，调节结肠免疫，减轻DSS诱导的UC。
Platycodon grandiflorus polysaccharide (PGP) is one of the main components of P. grandiflorus, but the mechanism of its anti-inflammatory effect has not been fully elucidated. The aim of this study was to evaluate the therapeutic effect of PGP on mice with dextran sodium sulfate (DSS)-induced ulcerative colitis (UC) and explore the underlying mechanisms. The results showed that PGP treatment inhibited the weight loss of DSS-induced UC mice, increased colon length, and reduced DAI, spleen index, and patho-logical damage within the colon. PGP also reduced the levels of pro-inflammatory cytokines and inhibited the enhancement of oxidat-ive stress and MPO activity. Meanwhile, PGP restored the levels of Th1, Th2, Th17, and Treg cell-related cytokines and transcription factors in the colon to regulate colonic immunity. Further studies revealed that PGP regulated the balance of colonic immune cells through mesenteric lymphatic circulation. Taken together, PGP exerts anti-inflammatory and anti-oxidant effect and regulates colonic immunity to attenuate DSS-induced UC through mesenteric lymphatic circulation.