New insights into the mechanism of DNA mismatch repair.
New insights into the mechanism of DNA mismatch repair.
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DOI：
10.1007/s00412-015-0514-0
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发表时间：
2015-12
期刊：
影响因子：
1.6
通讯作者：
Hombauer H
中科院分区：
文献类型：
--
作者：
Reyes GX;Schmidt TT;Kolodner RD;Hombauer H
所有生物体的基因组不断受到内源性和外源性DNA损伤的挑战。主要由DNA聚合酶在DNA复制过程中引入的碱基错配或小的插入和缺失等错误由进化保守的DNA错配修复（MMR）系统修复。MMR系统与DNA复制机制一起，在DNA复制期间或之后通过切除和再合成机制促进修复，将复制保真度提高多达三个数量级。因此，MMR基因的失活导致突变率升高，这可能导致人类癌症易感性增加。在这篇综述中，我们总结了我们目前对MMR的理解，重点是不同的MMR蛋白复合物，它们的功能和结构。我们还讨论了最近的研究结果提供了新的见解MMR的时空调控和机制。
The genome of all organisms is constantly being challenged by endogenous and exogenous sources of DNA damage. Errors like base:base mismatches or small insertions and deletions, primarily introduced by DNA polymerases during DNA replication are repaired by an evolutionary conserved DNA mismatch repair (MMR) system. The MMR system, together with the DNA replication machinery, promote repair by an excision and resynthesis mechanism during or after DNA replication, increasing replication fidelity by upto-three orders of magnitude. Consequently, inactivation of MMR genes results in elevated mutation rates that can lead to increased cancer susceptibility in humans. In this review, we summarize our current understanding of MMR with a focus on the different MMR protein complexes, their function and structure. We also discuss how recent findings have provided new insights in the spatio-temporal regulation and mechanism of MMR.