A functional HOTAIR rs920778 polymorphism does not contributes to gastric cancer in a Turkish population: a case-control study
A functional HOTAIR rs920778 polymorphism does not contributes to gastric cancer in a Turkish population: a case-control study
复制标题
DOI：
10.1007/s10689-015-9813-0
复制
发表时间：
2015-12-01
期刊：
影响因子：
2.2
通讯作者：
Rencuzogullari, Eyyup
中科院分区：
文献类型：
--
作者：
Bayram, Suleyman;Ulger, Yakup;Rencuzogullari, Eyyup
HOX转录反义基因间RNA(HOTAIR)是一种长的非编码RNA(LncRNA)，它的异常上调与包括胃癌在内的人类癌症和更糟糕的临床病理特征有关。HOTAIR基因内含子增强子中自然产生的功能性单核苷酸多态(SNP)rs920,778(C>；T)已被证明影响HOTAIR的表达和癌症的易感性。为探讨HOTAIR基因rs920778多态与土耳其人群GC易感性的关系，对104例GC和209例健康对照进行了以医院为基础的病例对照研究。采用TaqMan实时定量聚合酶链式反应检测HOTAIR基因rs920778多态的基因频率。HOTAIR rs920778基因多态在胃癌患者和健康对照组之间的等位基因和基因型分布差异无统计学意义(P>；0.05)。我们的结果表明，至少在这里研究的人群中，HOTAIR rs920778多态在胃癌发生的遗传易感性中没有任何主要作用。需要在更大的系列中以及在不同种族血统的患者中验证我们的发现，需要进行独立研究。
An aberrant up-regulation of HOX transcript antisense intergenic RNA (HOTAIR), a long non-coding RNA (lncRNA), is associated with human cancers including gastric cancer (GC) and worse clinicopathological features. A naturally occurring functional single nucleotide polymorphism (SNP) rs920,778 (C -> T) in the intronic enhancer of HOTAIR gene has been demonstrated to affect HOTAIR expression and cancer susceptibility. To investigate the association of the HOTAIR rs920778 polymorphism on the risk of GC susceptibility in Turkish population, a hospital-based case-control study was carried out consisting of 104 GC and 209 healthy control subjects matched on age and gender. The genotype frequency of HOTAIR rs920778 polymorphism was determined by using TaqMan Real-Time Polymerase Chain Reaction. No statistically significant differences were found in the allele or genotype distributions of the HOTAIR rs920778 polymorphism among GC and healthy control subjects (P > 0.05). Our results demonstrate that the HOTAIR rs920778 polymorphism has not been in any major role in genetic susceptibility to gastric carcinogenesis, at least in the population studied here. Independent studies are needed to validate our findings in a larger series, as well as in patients of different ethnic origins.