Low serum calcium is associated with left ventricular systolic dysfunction in a Chinese population with coronary artery disease.
Low serum calcium is associated with left ventricular systolic dysfunction in a Chinese population with coronary artery disease.
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低血清钙与中国冠状动脉疾病人群的左心室收缩功能障碍相关
DOI：
10.1038/srep22283
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发表时间：
2016-02-29
影响因子：
4.6
通讯作者：
Zhang R
中科院分区：
文献类型：
--
作者：
Wang Y;Ma H;Hao X;Yang J;Chen Q;Lu L;Zhang R
已确诊的冠状动脉疾病(CAD)和急性心肌梗死(AMI)患者的血钙是否与心脏收缩功能有关尚不清楚。本研究旨在评估血清钙与中国冠心病患者左心室收缩功能不全之间的关系。这项横断面研究包括了中国地区5938例合并和不合并急性心肌梗死的冠心病患者。评价与急性心肌梗死和左心室射血分数(LVEF)相关的因素。结果显示，急性心肌梗死患者血钙水平(2.11 ± 0.13vs2.20 ± 0.10 /L，P<； 0.001)明显低于非急性心肌梗死患者。多因素Logistic回归分析显示，血钙(OR：0.000，95%CI：0.000~0.001)是急性心肌梗死的独立危险因素之一。冠心病伴和不伴急性心肌梗死患者左心室射血分数为50%时的血钙水平均低于左心室射血分数为50%的≥时的血钙水平。多因素分析显示，冠心病伴和不伴急性心肌梗死患者血清钙水平分别与LVEF和LVEF<；50%独立相关。当左心室射血分数≥为50%时，冠心病患者血钙与左心室射血分数之间仍存在独立的相关性。急性心肌梗死后血钙水平显著降低。合并和不合并急性心肌梗死的冠心病患者中，低血钙与左心室收缩功能不全独立相关。
Whether serum calcium is associated with heart systolic function in patients with established coronary artery disease (CAD) and acute myocardial infarction (AMI) remains to be elucidated. This study is aimed to assess the association between serum calcium and left ventricular systolic dysfunction in a Chinese population of CAD. The cross-sectional study included 5938 CAD patients with and without AMI in China. The factors associated with AMI and left ventricular ejection fraction (LVEF) were evaluated. The data showed that AMI patients had lower serum calcium levels (2.11 ± 0.13 vs 2.20 ± 0.10 mmol/l,P< 0.001) than those without AMI. Multiple logistic regression analysis exhibited that serum calcium (OR: 0.000, 95% CI: 0.000–0.001) was one of the independent factors correlated with AMI. CAD patients with and without AMI when LVEF <50% had lower serum calcium levels than those when LVEF ≥50% respectively. Serum calcium was independently associated with LVEF and LVEF <50% in CAD patients with and without AMI respectively using multivariate analysis. The independent association between serum calcium and LVEF still existed among CAD patients when LVEF ≥50%. Serum calcium levels are significantly decreased following AMI. Low serum calcium is independently correlated with left ventricular systolic dysfunction in CAD patients with and without AMI.