Amaranth (Amaranthus cruentus L.) and canola (Brassica napus L.) oil impact on the oxidative metabolism of neutrophils in the obese patients
Amaranth (Amaranthus cruentus L.) and canola (Brassica napus L.) oil impact on the oxidative metabolism of neutrophils in the obese patients
复制标题
苋菜（Amaranthus cruentus L.）和菜籽油（Brassica napus L.）对肥胖患者中性粒细胞氧化代谢的影响
DOI：
10.1080/13880209.2019.1569696
复制
发表时间：
2019
影响因子：
3.8
通讯作者：
Witowski J
中科院分区：
文献类型：
--
作者：
Kanikowska D;Kanikowska A;Rutkowski R;Wlochal M;Orzechowska Z;Juchacz A;Zawada A;Grzymislawski M;Roszak M;Sato M;Breborowicz A;Witowski J
背景：苋菜油和菜籽油一直是传统的使用方法。由于其突出的营养价值，苋菜已被确定为有价值的植物。苋菜油是高度不饱和脂肪的丰富来源，因此对肥胖患者来说可能是一种有价值的饮食替代品。活性氧簇(ROS)被认为与全身炎症和氧化应激有关。目的：本研究旨在探讨补充籽粒苋油和菜籽油对肥胖患者氧化代谢的影响。我们假设，由于其降脂和抗氧化的特性，籽粒苋油和菜籽油可以抵抗氧化应激。材料和方法：我们测试了19名肥胖患者[体重指数 = 41.1 ± 7.8 kg/m2，(平均 ± SD)]。该方案包括两个阶段：2 周的磨合阶段和实验阶段--补充菜籽油或苋菜油(20 m L/d)，同时限制热量饮食，持续3 周。结果：两组患者在治疗结束时，中性粒细胞氧化猝发均显著增加，IF分别为(21.40± 11.15vs.35.9 ± 20.3；Mean ± SD)p <；接受菜籽油治疗的患者中性粒细胞IF水平(41.0 5 ± 2 5.3)明显高于接受籽粒扬油治疗的患者(2 8.4 ± 11.8)p<； 0.0 5。结论：菜籽油对中性粒细胞在活体条件下的氧化猝发活性可能有影响。
Context:Amaranth and canola oils have been used traditionally. Amaranth has been identified as being of interest because of its outstanding nutritive value. Amaranth oil is a rich source of highly unsaturated fats and so could be a valuable dietary alternative for individuals affected with obesity. Reactive oxygen species (ROS) are postulated to be involved in systemic inflammation and oxidative stress. Activated polymorphonuclear neutrophils (PMNs) generate high amounts of reactive oxygen species.Objective:Our study investigates the impact of amaranth and canola oils supplementation on oxidative metabolism in patients with obesity. We hypothesized that, due to its lipid-lowering and antioxidant properties, amaranth and canola oil would protect against oxidative stress.Materials and methods:We tested 19 obese patients [body mass index (BMI) = 41.1 ± 7.8 kg/m2, (mean ± SD)]. The protocol consisted of two stages: a run-in phase of 2 weeks and an experimental stage – canola or amaranth oil supplementation (20 mL/d) with calorie restriction diet for 3 weeks. The neutrophil oxidative burst was expressed by fluorescence intensity (IF).Results:The oxidative burst had increased significantly at the end of treatment in both groups IF: (21.4 ± 11.15 vs. 35.9 ± 20.3; mean ± SD)p <0.05. The levels of IF were significantly higher in neutrophils of patients who received canola oil (41.05 ± 25.3) compared to those who received amaranth oil (28.4 ± 11.8)p< 0.05.Conclusions:Canola oil exerts possible effects on oxidative burst activity in neutrophilsin vivoconditions.