On the emergence of biological complexity: Life as a kinetic state of matter
On the emergence of biological complexity: Life as a kinetic state of matter
复制标题
DOI：
10.1007/s11084-005-5272-1
复制
发表时间：
2005-04-01
影响因子：
2
通讯作者：
Pross, A
中科院分区：
文献类型：
--
作者：
Pross, A
提出了一个动力学模型，试图进一步阐明生物络合的本质。其本质是：复制系统的反应和常规化学系统的反应遵循不同的选择规则，导致不同的化学行为模式。常规化学系统的选择基本上是热力学的，而复制化学系统的选择实际上是动力学的。建立在动力学稳定性概念的扩展上，表明复杂复制子在动力学上比简单复制子更稳定，从而导致一个持续的动力学定向络合过程。简单的复制组件（如噬菌体）的高动力学稳定性，与组装组件的低动力学稳定性相比，说明了络合原理。分析表明，生命系统构成了一种物质的动力学状态，而不是主导无生命世界的传统热力学状态，并重申了我们的观点，即生命是复制化学的一种特殊表现。
A kinetic model that attempts to further clarify the nature of biological complexification is presented. Its essence: reactions of replicating systems and those of regular chemical systems follow different selection rules leading to different patterns of chemical behavior. For regular chemical systems selection is fundamentally thermodynamic, whereas for replicating chemical systems selection is effectively kinetic. Building on an extension of the kinetic stability concept it is shown that complex replicators, tend to be kinetically more stable than simple ones, leading to an on-going process of kinetically-directed complexification. The high kinetic stability of simple replicating assemblies such as phages, compared to the low kinetic stability of the assembly components, illustrates the complexification principle. The analysis suggests that living systems constitute a kinetic state of matter as opposed to the traditional thermodynamic states that dominate the inanimate world, and reaffirms our view that life is a particular manifestation of replicative chemistry.