Substance P as an immune modulator of anxiety.
Substance P as an immune modulator of anxiety.
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P物质作为焦虑的免疫调节剂。
DOI：
10.1159/000097314
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发表时间：
1997
影响因子：
2.4
通讯作者：
Douglas,SD
中科院分区：
文献类型：
--
作者：
Fehder,WP;Sachs,J;Uvaydova,M;Douglas,SD
已显示促炎肽物质P（SP）的外周血浓度响应于人类受试者中的心理焦虑而增加。在这项研究中，我们研究了外周血中SP水平的变化，以应对焦虑的诊断医疗程序。SP的水平被发现是较高的受试者与低初始焦虑的受试者相比，多情感形容词检查表测量的初始焦虑。CD-8表达的T淋巴细胞的百分比的变化被发现与焦虑的措施，以及SP的改变。这些变化持续3天后的诊断程序。研究结果表明，SP在应激诱导的免疫反应中可能起着介导作用。
Peripheral blood concentrations of the proinflammatory peptide substance P (SP) have been shown to increase in response to psychological anxiety in human subjects. In this study, we examined changes in SP levels in peripheral blood in response to the anxiety of a diagnostic medical procedure. The levels of SP were found to be higher in subjects with high initial anxiety as compared to subjects with low initial anxiety as measured on the Multiple Affect Adjective Checklist. Changes in the percentages of CD-8-expressing T lymphocytes were found to correlate with alterations in measures of anxiety as well as SP. These changes persisted for 3 days following the diagnostic procedure. The results of the study seem to indicate that SP may serve as a mediator in stress-induced immune reactions.