Expression of PINCH protein in gliomas and its clinicopathological significance
Expression of PINCH protein in gliomas and its clinicopathological significance
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DOI：
10.1159/000113064
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发表时间：
2007-01-01
期刊：
影响因子：
3.5
通讯作者：
Sun, Xiao-Feng
中科院分区：
文献类型：
--
作者：
Wang, Ming-Wei;Gu, Ping;Sun, Xiao-Feng
目的：特别有趣的新型半胱氨酸-组氨酸丰富蛋白（PINCH），作为LIM结构域适配蛋白，在整合素和生长因子信号转导通路中起作用，并在几种类型癌症的肿瘤相关基质中上调。然而，在胶质瘤中尚未开展PINCH的研究，因此我们检测了PINCH在胶质瘤中的表达及其临床病理意义。方法：对82例胶质瘤、26例相邻正常脑组织和10例复发胶质瘤进行免疫组化检测。结果：PINCH在原发肿瘤（35%,p = 0.0001）和复发肿瘤（40%,p = 0.004）中表达强烈，在正常脑组织中表达较弱。在高级别胶质瘤中，PINCH的表达显著增加（55% vs 24%，高级别胶质瘤vs低级别胶质瘤，p = 0.004）。PINCH的表达与性别、年龄、肿瘤数目、大小、组织学类型和肿瘤位置无相关性（p < 0.05）。结论：PINCH的表达可能参与了胶质瘤的发生和分化。版权所有2008 S. Karger AG，巴塞尔
Objectives: Particularly interesting new cysteine-histidinerich protein (PINCH), as a LIM domain adapter protein, functions in the integrin and growth factor signal transduction pathway, and is upregulated in tumor-associated stroma in several types of cancers. However, no study of PINCH has been carried out in gliomas, therefore we examined PINCH expression in gliomas and its clinicopathological significance. Methods: PINCH expression was immunohistochemically examined in 82 gliomas, along with 26 matched adjacent normal brain samples and 10 recurred gliomas. Results: PINCH was strongly expressed in the primary (35%, p = 0.0001) or recurred tumors (40%, p = 0.004) and weak in normal brain tissue. PINCH expression was significantly increased in high-grade gliomas (55 vs. 24%, high- vs. low-grade gliomas, p = 0.004). There was no association of PINCH expression with gender, age, tumor number, size, histological type and tumor location (p > 0.05). Conclusions: PINCH expression may be involved in glioma development and differentiation. Copyright (C) 2008 S. Karger AG, Basel.