Magnetic Field-Modulated Plasmonic Scattering of Hybrid Nanorods for FFT-Weighted OCT Imaging in NIR-II
Magnetic Field-Modulated Plasmonic Scattering of Hybrid Nanorods for FFT-Weighted OCT Imaging in NIR-II
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DOI：
10.1021/acsnano.2c04590
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发表时间：
2022-08-04
期刊：
影响因子：
17.1
通讯作者：
Yin，Yadong
中科院分区：
文献类型：
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作者：
Li，Zhiwei;Poon，Wesley;Yin，Yadong
我们报告了一种在第二生物组织透明窗口中通过使用磁场主动调制Fe3O4@Au混合纳米棒的等离子体散射进行快速傅里叶变换（FFT）加权光学相干断层扫描（OCT）的方法。我们不是在传统的磁动式OCT成像中跟踪纳米颗粒的横向位移，而是在真实的时间内监测纳米棒的旋转和交变磁场下的光信号变化。纳米棒随场的相干旋转产生周期性OCT信号，然后使用FFT将时域中的周期性OCT信号转换为频域中的单个峰值。这允许从随机生物噪声中自动筛选纳米棒信号，并使用基于时间序列图像集的计算机程序重建FFT加权图像。与传统的磁动式OCT相比，FFT加权成像技术创建了增强的OCT图像，其dB级对比度比原始图像高一个数量级。
We report a method for fast Fourier transform (FFT)-weighted optical coherence tomography (OCT) in the second biological tissue transparency window by actively modulating the plasmonic scattering of Fe3O4@Au hybrid nanorods using magnetic fields. Instead of tracking the nanoparticles’ lateral displacement in conventional magnetomotive OCT imaging, we monitor the nanorod rotation and optical signal changes under an alternating magnetic field in real time. The coherent rotation of the nanorods with the field produces periodic OCT signals, and the FFT is then used to convert the periodic OCT signals in the time domain to a single peak in the frequency domain. This allows automatic screening of nanorod signals from the random biological noises and reconstruction of FFT-weighted images using a computer program based on a time-sequence image set. Compared with conventional magnetomotive OCT, the FFT-weighted imaging technique creates enhanced OCT images with dB-scale contrast over an order of magnitude higher than the original images.