Induced pluripotent stem cell-derived vascular smooth muscle cells: methods and application.
Induced pluripotent stem cell-derived vascular smooth muscle cells: methods and application.
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DOI：
10.1042/bj20141078
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发表时间：
2015-01-15
期刊：
影响因子：
--
通讯作者：
Qyang Y
中科院分区：
文献类型：
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作者：
Dash BC;Jiang Z;Suh C;Qyang Y
Vascular smooth muscle cells (VSMCs) play a major role in the pathophysiology of cardiovascular diseases. The advent of induced pluripotent stem cell (iPSC) technology and their capability to differentiation into virtually every cell type in the human body make this field a ray of hope for vascular regenerative therapy and for understanding disease mechanism. In this review, we first discuss the recent iPSC technology and vascular smooth muscle development from embryo and then examine different methodology to derive VSMCs from iPSCs and their applications in regenerative therapy and disease modeling.
