The importance of CELF control: molecular and biological roles of the CUG-BP, Elav-like family of RNA-binding proteins.
The importance of CELF control: molecular and biological roles of the CUG-BP, Elav-like family of RNA-binding proteins.
复制标题
DOI：
10.1002/wrna.107
复制
发表时间：
2012-01
期刊：
影响因子：
--
通讯作者：
Ladd AN
中科院分区：
文献类型：
--
作者：
Dasgupta T;Ladd AN
RNA加工对于产生蛋白质多样性和调节蛋白质表达水平是重要的。RNA结合蛋白的CUG-BP，Elav-like家族（CELF）调节细胞核和细胞质中RNA加工的几个步骤，包括前体mRNA选择性剪接，C至U RNA编辑，去腺苷化，mRNA降解和翻译。在体内，CELF蛋白已被证明在配子发生和早期胚胎发育、心脏和骨骼肌功能以及神经突触传递中发挥作用。CELF介导的程序的失调已经涉及影响心脏、骨骼肌和神经系统的人类疾病的发病机制。
RNA processing is important for generating protein diversity and modulating levels of protein expression. The CUG-BP, Elav-like family (CELF) of RNA binding proteins regulate several steps of RNA processing in the nucleus and cytoplasm, including pre-mRNA alternative splicing, C to U RNA editing, deadenylation, mRNA decay, and translation. In vivo, CELF proteins have been shown to play roles in gametogenesis and early embryonic development, heart and skeletal muscle function, and neurosynaptic transmission. Dysregulation of CELF-mediated programs has been implicated in the pathogenesis of human diseases affecting the heart, skeletal muscles, and nervous system.