Human papillomavirus and cancer prevention: gaps in knowledge and prospects for research, policy, and advocacy.
Human papillomavirus and cancer prevention: gaps in knowledge and prospects for research, policy, and advocacy.
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DOI：
10.1016/j.vaccine.2012.06.092
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发表时间：
2012-11-20
期刊：
影响因子：
5.5
通讯作者：
Schiffman M
中科院分区：
文献类型：
--
作者：
Franco EL;de Sanjosé S;Broker TR;Stanley MA;Chevarie-Davis M;Isidean SD;Schiffman M
人们认识到人乳头瘤病毒 (HPV) 感染是宫颈癌的核心、必要原因，这为通过改进筛查方法和 HPV 疫苗接种开辟新的预防领域铺平了道路。从我们对 HPV 如何引起疾病的分子基础的理解，到个人和人群层面预防策略的健康经济学，我们在各个方面都学到了很多东西。其他癌症控制领域的进展尚未显示出与 HPV 相关恶性肿瘤研究中相同的多学科和跨学科成果，这是疾病预防领域明确的成功故事之一。然而，作为一种财富的尴尬，我们需要进行更多的研究来填补仍然存在的知识空白，然后我们才能从各个方面的知识转化中获益。针对特定环境实施基于 HPV 的预防策略的公共卫生研究以及更协调一致的宣传以消除采用这些策略所面临的障碍，可能会在减轻 HPV 相关疾病的负担方面产生重大成果。
The recognition that human papillomavirus (HPV) infection is the central, necessary cause of cervical cancer paved the way to new fronts of prevention via improved screening methods and HPV vaccination. Much has been learned in all fronts, from the molecular basis of our understanding of how HPV causes disease to the health economics of preventive strategies at the individual and population levels. Progress in other areas of cancer control has yet to show the same multi- and trans-disciplinary gains seen in research on HPV-associated malignancies, which is one of the unequivocal success stories in disease prevention. Yet, as an embarrassment of riches, much more research is needed to fill the gaps in knowledge that remain before we are able to reap the benefits from the knowledge translation from all fronts. Public health research on setting-specific implementation of HPV-based preventive strategies and more concerted advocacy to counter barriers facing the adoption of these strategies are likely to yield major dividends in reducing the burden of HPV-associated diseases.