Bone Morphogenetic Protein Coating on Titanium Implant Surface: a Systematic Review.
Bone Morphogenetic Protein Coating on Titanium Implant Surface: a Systematic Review.
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DOI：
10.5037/jomr.2017.8201
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发表时间：
2017-04
期刊：
影响因子：
--
通讯作者：
Juodzbalys G
中科院分区：
文献类型：
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作者：
Haimov H;Yosupov N;Pinchasov G;Juodzbalys G
本研究旨在系统综述钛种植体表面骨形态发生蛋白涂层对骨整合过程的改善作用。通过MEDLINE （PubMed）和EMBASE数据库进行电子文献检索。检索仅限于2006年10月至2016年9月过去10年间发表的文章，并且文章仅限于英语。共审阅了41篇文章，从中选出了8篇最符合标准的相关文章。文章分析了骨形态发生蛋白（BMP）的浓度、递送系统、不良反应以及BMP对体内骨和种植体周围表面的影响。最后，本数据包括340个植入物和236个模型。大多数研究都清楚地表明，骨形态发生蛋白能促进骨再生。为了诱导和维持骨形成活性，需要做进一步的研究。成骨剂应逐渐释放，不要快速释放，以三维储层（合并）钛种植体表面为优先，以免出现炎症、出血、血肿、水肿、红斑、移植物衰竭等严重副作用。
The purpose of the study is to systematically review the osseointegration process improvement by bone morphogenetic protein coating on titanium implant surface. An electronic literature search was conducted through the MEDLINE (PubMed) and EMBASE databases. The search was restricted for articles published during the last 10 years from October 2006 to September 2016 and articles were limited to English language. A total of 41 articles were reviewed, and 8 of the most relevant articles that are suitable to the criteria were selected. Articles were analysed regarding concentration of bone morphogenetic protein (BMP), delivery systems, adverse reactions and the influence of the BMP on the bone and peri-implant surface in vivo. Finally, the present data included 340 implants and 236 models. It’s clearly shown from most of the examined studies that bone morphogenetic protein increases bone regeneration. Further studies should be done in order to induce and sustain bone formation activity. Osteogenic agent should be gradually liberated and not rapidly released with priority to three-dimension reservoir (incorporated) titanium implant surface in order to avoid following severe side effects: inflammation, bleeding, haematoma, oedema, erythema, and graft failure.