HERITABILITY OF BRAIN SIZE AND SURFACE-FEATURES IN RHESUS MACAQUES (MACACA-MULATTA)
HERITABILITY OF BRAIN SIZE AND SURFACE-FEATURES IN RHESUS MACAQUES (MACACA-MULATTA)
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DOI：
10.1093/oxfordjournals.jhered.a110924
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发表时间：
1990-01-01
影响因子：
3.1
通讯作者：
HILDEBOLT, C
中科院分区：
文献类型：
--
作者：
CHEVERUD, JM;FALK, D;HILDEBOLT, C
整体大脑的大小和区域皮质表面特征，如沟长度的遗传程度是很重要的，以证明遗传成分观察到的个体间的表型差异，并评估潜在的进化变化，以应对选择。虽然大脑大小的遗传学已被广泛考虑，皮质表面的详细形态以前没有受到遗传分析。我们估计了遗传的大脑大小和皮质沟的长度，使用438从骨骼的恒河猴（Macaca mulatta）从卡约圣地亚哥人口的颅内铸型。通过母子回归和方差差异平方（SDS）方法获得估计值。以颅容量测量的大脑大小在这一人群中具有高度和显著的遗传性，证实了先前对实验室小鼠的研究结果。总的来说，皮质沟长度也是可遗传的，在母子分析中，35%的沟在5%的水平上具有显著的遗传性。平均母子遗传力估计值为0.31，与先前从一系列56个颅测量特征中获得的平均遗传力相同。SDS分析一般对应于母子回归的结果，虽然显着性检验似乎更保守。大脑的大体形态和细节形态都是可遗传的。
The extent of heritability for overall brain size and regional cortical surface features such as sulcus lengths is important for demonstrating a genetic component to the observed phenotypic differences among individuals and for evaluating the potential for evolutionary change in response to selection. Although the genetics of brain size has been extensively considered, the detailed morphology of the cortical surface has not previously been subjected to genetic analysis. We estimated the heritability of brain size and cortical sulcus lengths using 438 endocranial casts taken from skeletons of rhesus macaques (Macaca mulatta) from the Cayo Santiago population. Estimates were obtained both by mother-offspring regression and symmetric-difference-squared (SDS) methods. Brain size, measured as cranial capacity, was highly and significantly heritable in this population, confirming results of previous studies with laboratory mice. Overall, cortical sulcus lengths were also heritable, with 35% of the sulci significantly heritable at the 5% level in the mother-offspring analysis. The average mother-offspring heritability estimate, 0.31, was the same as the average heritability obtained previously from a series of 56 cranial metric characteris. The SDS analyses generally corresponded to the findings based on mother-offspring regressions, although the significance test appeared more conservative. Both gross and detailed morphology of the brain are heritable.