Sleep is atypical across neurodevelopmental disorders in infants and toddlers: A cross-syndrome study
Sleep is atypical across neurodevelopmental disorders in infants and toddlers: A cross-syndrome study
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DOI：
10.1016/j.ridd.2019.103549
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发表时间：
2020-02-01
影响因子：
3.1
通讯作者：
Karmiloff-Smith, Annette
中科院分区：
文献类型：
--
作者：
D'Souza, Dean;D'Souza, Hana;Karmiloff-Smith, Annette
这项跨综合症研究的重点是睡眠及其与语言发展的关系。患有神经发育障碍的儿童会出现语言迟缓。典型的语言发展受到包括睡眠在内的许多因素的限制。患有神经发育障碍的青少年/成人的睡眠经常受到干扰。因此，我们假设患有神经发育障碍的婴儿/幼儿的睡眠可能会受到干扰，并与语言发育相关。为了检验我们的假设，我们获得了 75 名患有三种神经发育障碍（唐氏综合症 [DS]、脆性 X 综合症 [FXS]、威廉姆斯综合症 [WS]）之一的婴儿/幼儿的睡眠和词汇量数据。这些孩子的睡眠确实受到了干扰。它还与患有 DS 和 WS 的婴儿/幼儿的接受词汇量呈正相关（由于缺乏能力，我们无法在 FXS 中测试睡眠和语言之间的关系）。我们认为，睡眠中断可能是患有神经发育障碍的幼儿的常见现象，这可能与他们习得母语的能力有关。
This cross-syndrome study focuses on sleep and its relationship with language development. Children with neurodevelopmental disorders present with language delay. Typical language development is constrained by numerous factors including sleep. Sleep is often disrupted in adolescents/adults with neurodevelopmental disorders. We therefore hypothesised that sleep may be disrupted, and correlate with language development, in infants/toddlers with neurodevelopmental disorders. To test our hypothesis, we obtained sleep and vocabulary size data from 75 infants/toddlers with one of three neurodevelopmental disorders (Down syndrome [DS], fragile X syndrome [FXS], Williams syndrome [WS]). Sleep was indeed disrupted in these children. It was also positively associated with receptive vocabulary size in the infants/toddlers with DS and WS (we could not test the relationship between sleep and language in FXS due to lack of power). We argue that disrupted sleep may be a common occurrence in very young children with neurodevelopmental disorders, and it may relate to their ability to acquire their first language.