New thoughts on the pathophysiology of osteoarthritis: one more step toward new therapeutic targets.
New thoughts on the pathophysiology of osteoarthritis: one more step toward new therapeutic targets.
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DOI：
10.1007/s11926-006-0022-6
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发表时间：
2006-02-01
影响因子：
5
通讯作者：
Pelletier, Jean-Pierre
中科院分区：
文献类型：
--
作者：
Martel-Pelletier, Johanne;Lajeunesse, Daniel;Pelletier, Jean-Pierre
骨关节炎被认为是一种疾病，其中关节组织之间的复杂相互作用在这种病理生理学的开始和/或进展中起着重要作用。我们还没有完全了解导致关节组织退化和丧失的所有因素。本文总结了三个这样的机制的新颖性。第一个指向一些参与调节一个生长因子家族的因子，骨形态发生蛋白，第二个，前列腺素E（2）合成的调节，第三个涉及软骨下骨重塑的因子，所有这些都可能是骨关节炎非常重要的事件。这篇论文应该帮助读者更好地了解这些因素在这种疾病过程中的作用的最新进展，以及如何确定新的治疗靶点。
Osteoarthritis is considered an illness in which a complex interaction between the tissues of the joint plays a significant role in the initiation and/or progression of this pathophysiology. We do not yet completely understand all the factors that are responsible for initiating the degradation and loss of the articular tissues. This paper summarizes the novelties of three such mechanisms. The first one points to some factors involved in the regulation of one growth factor family, the bone morphogenetic proteins, the second, the regulation of prostaglandin E(2) synthesis, and the third the factors involved in subchondral bone remodeling, all of which could be very significant events for osteoarthritis. This paper should help the reader better understand the most recent advances regarding the roles of these factors in this disease process, and how new therapeutic targets may be identified.