Parenteral and enteral metabolism of anaplerotic triheptanoin in normal rats
Parenteral and enteral metabolism of anaplerotic triheptanoin in normal rats
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DOI：
10.1152/ajpendo.00366.2005
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发表时间：
2006-10-01
影响因子：
5.1
通讯作者：
Brunengraber, Henri
中科院分区：
文献类型：
--
作者：
Kinman, Renee P.;Kasumov, Takhar;Brunengraber, Henri
对遗传性长链脂肪酸氧化障碍的一种新的慢性治疗方法包括将高达三分之一的饮食卡路里作为三庚酸，一种中奇链甘油三酯(Roe CR，Sweetman L，Roe DS，David F和Brunengraber H.J Clin Invest 110：259-269,2002)。庚酸和C-5-酮体在肝脏中的部分氧化形成的C-5-酮小体是外周组织中抗丙酰辅酶A的前体。据推测，增加外周组织的回缩会促进能量的产生。在本研究中，我们测试了三庚烷乳剂作为静脉营养素的潜力。正常大鼠静脉或十二指肠内注入高达所需热量的40%的三庚烷。静脉注射时血药浓度比(庚酸/C-5-酮体)高，十二指肠内注射时血药浓度比低。在静脉输注三庚烷时，脂肪分解被刺激，但似乎被脂肪酸再酯化补偿。十二指肠内注射三庚烷时，不会刺激脂解作用。我们的数据支持这样的假设，即静脉注射三庚烷可以用于治疗失代偿期长链脂肪酸氧化障碍患者。
A new chronic treatment for inherited disorders of long-chain fatty acid oxidation involves administering up to one-third of dietary calories as triheptanoin, a medium-odd-chain triglyceride (Roe CR, Sweetman L, Roe DS, David F, and Brunengraber H. J Clin Invest 110: 259-269, 2002). Heptanoate and C-5-ketone bodies derived from its partial oxidation in liver are precursors of anaplerotic propionyl-CoA in peripheral tissues. It was hypothesized that increasing anaplerosis in peripheral tissues would boost energy production. In the present study, we tested the potential of a triheptanoin emulsion as an intravenous nutrient. Normal rats were infused with triheptanoin intravenously or intraduodenally at up to 40% of caloric requirement. The blood concentration ratio (heptanoate/C-5-ketone bodies) was high with intravenous and low with intraduodenal triheptanoin infusion. During intravenous infusion of triheptanoin, lipolysis was stimulated but appeared compensated by fatty acid reesterification. During intraduodenal infusion of triheptanoin, lipolysis was not stimulated. Our data support the hypothesis that intravenous triheptanoin could be used to treat decompensated patients with long-chain fatty acid oxidation disorders.