A model of experimental isolation perfusion using cis‐platinum
A model of experimental isolation perfusion using cis‐platinum
复制标题
使用顺铂的实验隔离灌注模型
DOI：
10.1002/jso.2930210110
复制
发表时间：
1982
影响因子：
2.5
通讯作者：
G. Mason
中科院分区：
文献类型：
--
作者：
A. Wile;E. Guilmette;H. Friedberg;H. Friedberg;G. Mason
已经设计了一种动物模型来研究高温和化疗药物对正常组织和肿瘤组织的影响。该模型以兔为实验动物，将允许可移植的VX-2肿瘤通过。该技术类似于临床隔离-灌流，并使用顺铂作为化疗药物。这一模型已被证明在治疗范围内获得组织温度方面是可靠和一致的，并证明了在这种治疗模式中使用顺铂的安全性。
An animal model has been devised to investigate effects of hyperthermia and chemotherapeutic agents on normal and neoplastic tissue. This model uses the rabbit as the experimental animal and will permit the passage of the transplantable VX‐2 carcinoma. The technique described parallels clinical isolation‐perfusion and utilizes cis‐platinum as the chemotherapeutic agent. This model has proven to be reliable and consistent in achieving tissue temperature at therapeutic ranges and has documented the safety of using cis‐platinum in this mode of therapy.