Body size, weight change, fat distribution and breast cancer risk in Hispanic and non-Hispanic white women
Body size, weight change, fat distribution and breast cancer risk in Hispanic and non-Hispanic white women
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DOI：
10.1007/s10549-006-9292-y
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发表时间：
2007-03-01
影响因子：
3.8
通讯作者：
Byers, Tim
中科院分区：
文献类型：
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作者：
Slattery, Martha L.;Sweeney, Carol;Byers, Tim
导言乳腺癌的发病率在居住在美国西南部的妇女中有所不同。方法将1999年10月1日至2004年5月居住在亚利桑那州、科罗拉多州、新墨西哥州或犹他州的乳腺癌患者(n=2325)与对照组(n=2525)进行配对。结果15岁时体重指数(BMI)与绝经前乳腺癌风险呈负相关(OR值分别为0.68和0.68，95%CI分别为0.44、1.04和0.65 95%CI 0.39、1.08)；15岁时BMI对绝经后肥胖的乳腺癌风险也有影响。在绝经后的女性中，最近接触到的激素是与体型相关的风险的重要修饰者。在最近没有接触激素的妇女中，NHW妇女肥胖的风险为1.61(95%CI 1.05，2.45)；在15岁至50岁之间增加25公斤的西班牙裔妇女中，与乳腺癌呈负相关(OR 0.51，95%CI 0.23，1.14)。体重增加和腰臀比(WHR)大与患雌激素受体阴性肿瘤的几率增加有关(OR1.81，95%CI 1.07，3.08和2.04，95%CI 1.20，3.50)。结论这些发现表明，肥胖对乳腺癌风险的代谢后果在居住在西南部的NHW和西班牙裔女性中有所不同。
Introduction The incidence of breast cancer varies among women living in the Southwestern part of the US. We evaluate how body size influences breast cancer risk among these women.Methods Cases (n = 2,325) diagnosed with breast cancer between October 1, 1999 and May 2004 residing in Arizona, Colorado, New Mexico, or Utah were matched to controls (n = 2,525). Participants were interviewed; height, weight, waist, and hip circumference were measured at the time of interview; blood was drawn.Results A large body mass index (BMI) at age 15 was inversely associated with pre-menopausal breast cancer risk in both non-Hispanic white (NHW) and Hispanic women (Odds ratio, ORs 0.68 95% CI 0.44, 1.04, and 0.65 95% CI 0.39, 1.08, respectively); BMI at age 15 also had an impact on subsequent breast cancer associated with obesity after menopause. Among post-menopausal women, recent exposure to hormones was an important modifier of risk associated with body size. Among women not recently exposed to hormones risk associated with obesity was 1.61 (95% CI 1.05, 2.45) for NHW women; gaining >= 25 kg between 15 and age 50 was inversely associated with breast cancer among Hispanic women (OR 0.51, 95% CI 0.23, 1.14). A large weight gain and a large waist-to-hip ratio (WHR) was associated with an increased odds of having an estrogen receptor negative tumor among NHW only (OR 1.81, 95% CI 1.07, 3.08, and 2.04 95% CI 1.20,3.50).Conclusions These findings suggest that the metabolic consequences of obesity on breast cancer risk differ between NHW and Hispanic women living in the Southwest.