Handheld ultrahigh speed swept source optical coherence tomography instrument using a MEMS scanning mirror
Handheld ultrahigh speed swept source optical coherence tomography instrument using a MEMS scanning mirror
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DOI：
10.1364/boe.5.000293
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发表时间：
2014-01-01
影响因子：
3.4
通讯作者：
Fujimoto, James G.
中科院分区：
文献类型：
--
作者：
Lu, Chen D.;Kraus, Martin F.;Fujimoto, James G.
我们开发了一种使用 2D MEMS 镜的超高速手持式扫频源光学相干断层扫描 (SS-OCT) 眼科仪器。垂直腔表面发射激光器 (VCSEL) 在 1060 nm 中心波长下工作，在组织中产生 350 kHz 轴向扫描速率和 10 μm 轴向分辨率。 VCSEL 的长相干长度可实现 3.08 毫米的成像范围，并且组织中的灵敏度滚降最小。对具有相同光学组件的两种不同设计进行了测试，以评估手持式 OCT 人体工程学。虹膜相机帮助通过瞳孔对准 OCT 光束，手动固定灯选择视网膜上的成像区域。从 5 名未散瞳的正常受试者获得体积和高清扫描。通过在快方向正弦扫描和在正交慢方向线性扫描 2.4 mm 直径 2D MEMS 镜来获取体积 OCT 数据。在正交方向上获得第二次体积正弦扫描，并使用软件算法处理两个体积以生成合并的运动校正体积。使用两次体积扫描生成运动校正标准 6 x 6 mm(2) 和宽视野 10 x 10 mm(2) 体积 OCT 数据，每次扫描仅需 1.4 秒。高清 10 毫米和 6 毫米 B 扫描是通过对 0.57 秒内在同一位置获得的 25 个 B 扫描进行平均和记录而获得的。体积 OCT 数据的优点之一是生成正面 OCT 图像，其中任意横截面 B 扫描与眼底特征配准。这项技术应该能够在不可逆的视力损伤或丧失发生之前，使筛查应用能够识别早期视网膜疾病。手持式 OCT 技术还有望在传统眼科或验光诊所之外的广泛环境中应用，包括儿科、术中、初级保健、发展中国家和军事医学。 (C) 2013 美国光学学会
We developed an ultrahigh speed, handheld swept source optical coherence tomography (SS-OCT) ophthalmic instrument using a 2D MEMS mirror. A vertical cavity surface-emitting laser (VCSEL) operating at 1060 nm center wavelength yielded a 350 kHz axial scan rate and 10 mu m axial resolution in tissue. The long coherence length of the VCSEL enabled a 3.08 mm imaging range with minimal sensitivity roll-off in tissue. Two different designs with identical optical components were tested to evaluate handheld OCT ergonomics. An iris camera aided in alignment of the OCT beam through the pupil and a manual fixation light selected the imaging region on the retina. Volumetric and high definition scans were obtained from 5 undilated normal subjects. Volumetric OCT data was acquired by scanning the 2.4 mm diameter 2D MEMS mirror sinusoidally in the fast direction and linearly in the orthogonal slow direction. A second volumetric sinusoidal scan was obtained in the orthogonal direction and the two volumes were processed with a software algorithm to generate a merged motion-corrected volume. Motion-corrected standard 6 x 6 mm(2) and wide field 10 x 10 mm(2) volumetric OCT data were generated using two volumetric scans, each obtained in 1.4 seconds. High definition 10 mm and 6 mm B-scans were obtained by averaging and registering 25 B-scans obtained over the same position in 0.57 seconds. One of the advantages of volumetric OCT data is the generation of en face OCT images with arbitrary cross sectional B-scans registered to fundus features. This technology should enable screening applications to identify early retinal disease, before irreversible vision impairment or loss occurs. Handheld OCT technology also promises to enable applications in a wide range of settings outside of the traditional ophthalmology or optometry clinics including pediatrics, intraoperative, primary care, developing countries, and military medicine. (C) 2013 Optical Society of America