Six types of tea reduce high-fat-diet-induced fat accumulation in mice by increasing lipid metabolism and suppressing inflammation
Six types of tea reduce high-fat-diet-induced fat accumulation in mice by increasing lipid metabolism and suppressing inflammation
复制标题
六种茶通过增加脂质代谢和抑制炎症来减少高脂肪饮食引起的小鼠脂肪堆积
DOI：
10.1039/c8fo02334d
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发表时间：
2019-04-01
期刊：
影响因子：
6.1
通讯作者：
Cao, Fanrong
中科院分区：
文献类型：
--
作者：
Liu, Chen;Guo, Yuntong;Cao, Fanrong
高脂肪饮食会导致肥胖，因为白色脂肪堆积。虽然茶提取物可以缓解脂质代谢紊乱，减少白色脂肪的积累，但不同类型的中国茶的治疗作用机制尚不清楚。我们通过给小鼠喂食高脂饮食（HFD）并用阿托伐他汀（阳性对照）或不同茶类型的水提取物（WEAT）治疗它们来建立肥胖小鼠模型。评价食物和水摄入量、体重增加、白色脂肪积累以及甘油三酯（TG）和总胆固醇（TC）水平，以评估WEAT对肥胖的影响。测定脂代谢酶p-AMPK、CPT-1A、FAS及促炎因子iNOS、IL-6水平。WEAT不仅降低了HFD诱导的肥胖小鼠的体重和白色脂肪积累，而且减轻了肝脏脂肪变性。比较六种茶的减肥效果，发现白色茶的减肥效果最好。黄茶和生普洱茶显著上调p-AMPK，绿色茶、白色茶和生普洱茶显著抑制FAS，白色茶、黄茶和乌龙茶上调CPT-1。因此，可能白色茶、黄茶和乌龙茶通过增加能量消耗和脂肪酸氧化来抑制肥胖，而绿色、白色茶和生普洱茶则通过抑制脂肪酸合成来发挥作用。此外，WEAT还显著降低IL-6的水平，而绿色茶、黄茶和乌龙茶显著抑制iNOS。不同类型的茶具有特定的化学成分，可以调节不同的脂质代谢相关蛋白。总之，尽管茶的成分和作用机制各不相同，但茶是一种有效的抗肥胖剂。
A high-fat diet results in obesity because of white fat accumulation. Although tea extracts alleviate lipid metabolism disorders and decrease white fat accumulation, the mechanisms underlying the therapeutic actions of different types of Chinese tea are unclear. We established a murine model of obesity by feeding mice with a high-fat diet (HFD) and treating them with atorvastatin (positive control) or water extracts (WEATs) of different tea types. The food and water intake, body weight gain, white fat accumulation, and triglyceride (TG) and total cholesterol (TC) levels were evaluated to assess the effects of the WEATs on obesity. The levels of the lipid metabolism enzymes p-AMPK, CPT-1A and FAS and the pro-inflammatory factors iNOS and IL-6 were determined. The WEATs not only reduced the body weight and white fat accumulation in the HFD-induced obese mice, but also relieved hepatic steatosis. Comparing the effects of the six kinds of tea showed that white tea has the best anti-obesity effect. Yellow tea and raw pu-erh tea significantly up-regulated p-AMPK, green tea, white tea and raw pu-erh tea markedly inhibited FAS, and white tea, yellow tea and oolong tea up-regulated CPT-1. Therefore, it is possible that white tea, yellow tea and oolong tea inhibit obesity by increasing energy expenditure and fatty acid oxidation, while green tea, white tea and raw pu-erh tea exert their effects by inhibiting fatty acid synthesis. In addition, the WEATs also significantly decreased the levels of IL-6, while green tea, yellow tea and oolong tea significantly inhibited iNOS. Different types of tea have specific chemical compositions and can regulate different lipid metabolism related proteins. In conclusion, despite variations in its composition and mechanism of action, tea is a potent anti-obesity agent.