Altered Chemokine Th1/Th2 Balance in Addison's Disease: Relationship with Hydrocortisone Dosing and Quality of Life
Altered Chemokine Th1/Th2 Balance in Addison's Disease: Relationship with Hydrocortisone Dosing and Quality of Life
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DOI：
10.1055/s-0033-1351291
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发表时间：
2014-01-01
影响因子：
2.2
通讯作者：
Wahlberg, J.
中科院分区：
文献类型：
--
作者：
Ekman, B.;Alstrand, N.;Wahlberg, J.
在自身免疫性艾迪生氏病（AAD）中发现的肾上腺炎被认为具有TH1驱动的发病机理。循环Th1和Th2相关的趋化因子负责将白细胞贩运到炎症部位是Th1/Th2平衡的标志。该研究的目的是评估2或4剂量给患有AAD患者的每日氢化可的松剂量是否可能影响循环趋化因子的Th1/Th2平衡。这项随机，安慰剂控制的双盲跨界研究中包括15例患者（6名女性）。趋化因子，Th1相关（CXCL10，CXCL11）和Th2相关（CCL17，CCL22）的样品在每个治疗期结束时的24小时内绘制了5次，并用Luminex分析。七个对照受试者一次进行相同的昼夜血液采样。具有AAD的受试者的Th1相关趋化因子的中位昼夜水平高于对照组[43（33-56）Pg/ml vs.22（19-34）PG/ml，P，P
The adrenalitis found in autoimmune Addison's disease (AAD) is considered having a Th1-driven pathogenesis. Circulating Th1- and Th2-associated chemokines responsible for the trafficking of leukocytes to inflammatory sites are markers for the Th1/Th2 balance. The aim of the study was to assess if the same daily hydrocortisone dose of 30mg given in either 2 or 4 doses to patients with AAD could affect the Th1/Th2 balance of circulating chemokines. Fifteen patients (6 women) with AAD were included in this randomised, placebo controlled, double blind cross-over study. Samples for chemokines, Th1-associated (CXCL10, CXCL11) and Th2-associated (CCL17, CCL22), were drawn 5 times during a 24-h period at the end of each treatment period and analysed with Luminex. Seven control subjects did the same diurnal blood sampling once. Subjects with AAD had higher median diurnal levels of the Th1-associated chemokines than controls, CXCL10 [43 (33-56) pg/ml vs. 22 (19-34) pg/ml, p