Experience-dependent expression of miR-132 regulates ocular dominance plasticity.
Experience-dependent expression of miR-132 regulates ocular dominance plasticity.
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DOI：
10.1038/nn.2920
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发表时间：
2011-09-04
影响因子：
25
通讯作者：
Pizzorusso T
中科院分区：
文献类型：
--
作者：
Tognini P;Putignano E;Coatti A;Pizzorusso T
miR 132是CREB诱导的参与树突棘可塑性的microRNA。我们观察到，视觉经验调节组蛋白翻译后修饰CRE基因座重要的miR 212/132簇转录和miR 132在幼年小鼠的视觉皮层的表达。单眼剥夺降低了剥夺眼对侧皮质中的miR 132表达。通过输注化学修饰的miR 132模拟寡核苷酸抵消miR 132减少完全阻断了眼优势可塑性（ODP）。
MiR132 is a CREB induced microRNA involved in dendritic spine plasticity. We observed that visual experience regulates histone post-translational modifications at a CRE locus important for miR212/132 cluster transcription and miR132 expression in the visual cortex of juvenile mice. Monocular deprivation reduced miR132 expression in the cortex contralateral to the deprived eye. Counteracting miR132 reduction with infusion of chemically modified miR132 mimic oligonucleotides completely blocked ocular dominance plasticity (ODP).