Genomic Basis for Methicillin Resistance in Staphylococcus aureus.
Genomic Basis for Methicillin Resistance in Staphylococcus aureus.
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DOI：
10.3947/ic.2013.45.2.117
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发表时间：
2013-06
影响因子：
4.2
通讯作者：
Baba T
中科院分区：
文献类型：
--
作者：
Hiramatsu K;Ito T;Tsubakishita S;Sasaki T;Takeuchi F;Morimoto Y;Katayama Y;Matsuo M;Kuwahara-Arai K;Hishinuma T;Baba T
自 1961 年在英国发现第一株菌株以来，MRSA 作为最臭名昭著的多重耐药性医院病原体，已蔓延到世界各地。 MRSA 多次拒绝了现代有机化学成果——多种化疗药物的挑战。现在，我们缺乏针对医院免疫功能低下患者中流行的 MRSA 的有效治疗药物。除此之外，我们最近意识到 MRSA 多种克隆的兴起，其中一些与传统的医院相关 MRSA 相比具有更高的致病潜力，而其他克隆则来自兽医。它们在社区中迅速增加，并开始通过引起意外的急性感染来威胁其他健康的个体。这篇综述旨在根据 MRSA 作为一种多用途病原体和我们顽强的殖民者的基因组成，提供其全貌。
Since the discovery of the first strain in 1961 in England, MRSA, the most notorious multidrug-resistant hospital pathogen, has spread all over the world. MRSA repeatedly turned down the challenges by number of chemotherapeutics, the fruits of modern organic chemistry. Now, we are in short of effective therapeutic agents against MRSA prevailing among immuno-compromised patients in the hospital. On top of this, we recently became aware of the rise of diverse clones of MRSA, some of which have increased pathogenic potential compared to the classical hospital-associated MRSA, and the others from veterinary sources. They increased rapidly in the community, and started menacing otherwise healthy individuals by causing unexpected acute infection. This review is intended to provide a whole picture of MRSA based on its genetic makeup as a versatile pathogen and our tenacious colonizer.