IN VITRO THROMBOLYTIC EFFICACY OF SINGLE- AND FIVE-CYCLE HISTOTRIPSY PULSES AND RT-PA
IN VITRO THROMBOLYTIC EFFICACY OF SINGLE- AND FIVE-CYCLE HISTOTRIPSY PULSES AND RT-PA
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DOI：
10.1016/j.ultrasmedbio.2019.10.009
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发表时间：
2020-02-01
影响因子：
2.9
通讯作者：
Bader, Kenneth B.
中科院分区：
文献类型：
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作者：
Bollen, Viktor;Hendley, Samuel A.;Bader, Kenneth B.
虽然组织电切主要被认为是一种消融方式，但在回缩的静脉血栓模型中，组织电切可以增加溶解治疗的效果。气泡云振荡是组织摩擦学的主要作用机制，气泡活动的类型取决于脉冲持续时间。用溶栓重组组织型纤溶酶原激活剂(rt-PA)灌流回缩的人静脉血栓模型。血栓暴露于单周期或五周期的组织学脉冲，峰值负压为0-30兆帕。通过被动空化成像监测血栓内的气泡活动。对于峰值负压分别为25 Mpa和20 Mpa的单周期和5周期脉冲，组织摩擦和rt-PA联合应用较单独使用rt-PA更有效。对于两种激发方案，检测到的声发射与溶栓疗效的程度相关。这些结果表明，rt-PA和单周期或多周期组织碎石脉冲可加强溶栓治疗。(C)2019年提交人(S)。由爱思唯尔公司代表世界医学和生物学超声联合会出版。
Although primarily known as an ablative modality, histotripsy can increase the efficacy of lytic therapy in a retracted venous clot model. Bubble cloud oscillations are the primary mechanism of action for histotripsy, and the type of bubble activity is dependent on the pulse duration. A retracted human venous clot model was perfused with and without the thrombolytic recombinant tissue plasminogen activator (rt-PA). The clot was exposed to histotripsy pulses of single- or five-cycle duration and peak negative pressures of 0-30 MPa. Bubble activity within the clot was monitored via passive cavitation imaging. The combination of histotripsy and rt-PA was more efficacious than rt-PA alone for single- and five-cycle pulses with peak negative pressures of 25 and 20 MPa, respectively. For both excitation schemes, the detected acoustic emissions correlated with the degree of thrombolytic efficacy. These results indicate that rt-PA and single- or multicycle histotripsy pulses enhance thrombolytic therapy. (C) 2019 The Author(s). Published by Elsevier Inc. on behalf of World Federation for Ultrasound in Medicine & Biology.