Risk factors for vitamin D deficiency and relationship with cardiac biomarkers, inflammation and immune restoration in HIV-infected youth.
Risk factors for vitamin D deficiency and relationship with cardiac biomarkers, inflammation and immune restoration in HIV-infected youth.
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DOI：
10.3851/imp2318
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发表时间：
2012
影响因子：
1.2
通讯作者：
McComsey GA
中科院分区：
文献类型：
--
作者：
Eckard AR;Judd SE;Ziegler TR;Camacho-Gonzalez AF;Fitzpatrick AM;Hadley GR;Grossmann RE;Seaton L;Seydafkan S;Mulligan MJ;Rimann N;Tangpricha V;McComsey GA
维生素D缺乏在艾滋病毒感染者中很常见。在成人中，传统因素和艾滋病毒相关因素在维生素D状态中发挥作用，缺乏维生素D似乎会损害免疫恢复并加剧艾滋病毒并发症，如心血管疾病（CVD）。本研究旨在确定影响hiv感染青年维生素D状态的因素，并调查其与心血管疾病风险、炎症和免疫恢复的关系。hiv感染的受试者（1-25岁）与按年龄、性别和种族分组匹配的健康对照一起被前瞻性地纳入研究。收集艾滋病毒感染组的艾滋病毒数据，同时收集两组的传统风险因素，包括维生素D摄入量、日晒、皮肤色素沉着、身体活动水平和体重指数（BMI）。测定空腹血脂、血浆25-羟基维生素D （25(OH)D）和炎症标志物。纳入了200名艾滋病毒感染者和50名对照者。HIV组男性占53%，黑人占95%，平均年龄17.2±4.6岁。25(OH)D在两组间无差异；77%的HIV阳性和74%的对照组25(OH)D <20 ng/mL。只有Fitzpatrick皮肤类型与25(OH)D独立相关。没有HIV变量与25(OH)D相关，即使在检测HIV亚群时也是如此。炎症、CVD危险因素和免疫恢复与25(OH)D无关。维生素D缺乏在感染艾滋病毒的青年中很常见。然而，HIV因素、心血管疾病风险、炎症和免疫恢复似乎与维生素D的关系并不像在成人中所显示的那样。需要补充试验来确定增加25(OH)D浓度是否能更好地阐明这些关系。
Vitamin D deficiency is common in HIV-infected individuals. In adults, traditional and HIV-related factors play a role in vitamin D status, and deficiency appears to impair immune restoration and exacerbate HIV complications, like cardiovascular disease (CVD). This study sought to determine factors contributing to vitamin D status in HIV-infected youth and investigate the relationship with CVD risk, inflammation, and immune restoration. HIV-infected subjects (1–25 years old) were enrolled prospectively along with healthy controls that were group-matched by age, sex, and race. HIV data were collected for the HIV-infected group, while traditional risk factors, including vitamin D intake, sun exposure, skin pigmentation, physical activity level, and body mass index (BMI) were collected for both groups. Fasting lipids, plasma 25-hydroxyvitamin D (25(OH)D), and inflammation markers were measured. 200 HIV-infected subjects and 50 controls were enrolled. HIV group had 53% male, 95% black, and a mean age of 17.2±4.6 years. There was no difference in 25(OH)D between groups; 77% of HIV+ and 74% of controls had 25(OH)D <20 ng/mL. Only Fitzpatrick skin type was independently associated with 25(OH)D. No HIV variables were associated with 25(OH)D, even when HIV sub-populations were examined. Inflammation, CVD risk factors, and immune restoration were not independently associated with 25(OH)D. Vitamin D deficiency is common among HIV-infected youth. However, HIV factors, CVD risk, inflammation, and immune restoration do not appear to have the same relationship with vitamin D as has been shown in adults. Supplementation trials are needed to determine if increasing 25(OH)D concentrations could better elucidate these relationships.