Structural Basis of GABAB Receptor Regulation and Signaling
Structural Basis of GABAB Receptor Regulation and Signaling
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DOI：
10.1007/7854_2020_147
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发表时间：
2022-01-01
期刊：
影响因子：
--
通讯作者：
Bettler, Bernhard
中科院分区：
文献类型：
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作者：
Fritzius, Thorsten;Stawarski, Michal;Bettler, Bernhard
GABA（B）受体（GBR）是抑制性神经递质γ-氨基丁酸（GABA）的G蛋白偶联受体，其激活调节腺苷酸环化酶、Ca 2+通道和K+通道的Go/i型G蛋白。GBR向酶和离子通道的信号传导影响整个大脑的神经元活动、可塑性过程和网络活动。GBR是由GB 1a或GB 1b亚基与GB 2亚基组成的专性异二聚体。异源二聚体GB 1a/2和GB 1b/ 2受体代表以模块化方式与调节、运输和效应蛋白关联以产生具有不同生理功能的受体的功能单元。本文综述了多蛋白GBR复合物的结构、组织和功能。
GABA(B) receptors (GBRs), the G protein-coupled receptors for the inhibitory neurotransmitter gamma-aminobutyric acid (GABA), activate Go/i-type G proteins that regulate adenylyl cyclase, Ca2+ channels, and K+ channels. GBR signaling to enzymes and ion channels influences neuronal activity, plasticity processes, and network activity throughout the brain. GBRs are obligatory heterodimers composed of GB1a or GB1b subunits with a GB2 subunit. Heterodimeric GB1a/2 and GB1b/ 2 receptors represent functional units that associate in a modular fashion with regulatory, trafficking, and effector proteins to generate receptors with distinct physiological functions. This review summarizes current knowledge on the structure, organization, and functions of multi-protein GBR complexes.