Synaptic differences in the postmortem striatum of subjects with schizophrenia: a stereological ultrastructural analysis.
Synaptic differences in the postmortem striatum of subjects with schizophrenia: a stereological ultrastructural analysis.
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精神分裂症患者死后纹状体的突触差异：体视超微结构分析。
DOI：
10.1002/syn.20144
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发表时间：
2005
期刊：
影响因子：
--
通讯作者：
Conley,RobertR
中科院分区：
文献类型：
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作者：
Roberts,RosalindaC;Roche,JoyK;Conley,RobertR
纹状体处理运动、认知和边缘功能，所有这些功能在精神分裂症中都会受到干扰。本研究检查了精神分裂症中尾状核和壳核的突触组织。死后纹状体取自 10 名正常对照 (NC) 和 17 名精神分裂症患者 (SZ)，准备用于电子显微镜检查，并使用体视学原理进行分析。与 NC 相比，SZ 尾状核中总突触、不对称突触（兴奋性输入的特征）和不对称轴棘突触（皮质输入的特征）的密度较高。这些变化在非药物 SZ 病例中最为显着，并且在服用抗精神病药物 (APD) 的受试者中也有所升高。与 NC 相比，SZ 队列整体的壳核没有显着差异；然而，非药物亚组中有更多不对称轴棘突触。 SZ 中突触密度的增加似乎不是由抗精神病药物引起的，可能代表正常突触修剪失败或异常萌芽。与 NC 相比，SZ 中皮质型突触的密度更高可能反映了皮质纹状体回路的适应或纹状体投射神经元的过度刺激。异常的突触组织可能会产生几种重要且不同的下游影响，具体取决于所涉及的精确电路，并且可能与精神分裂症的边缘或认知功能障碍有关。 Synapse 56:185–197, 2005。© 2005 Wiley-Liss, Inc.
The striatum processes motor, cognitive, and limbic function, all of which are perturbed in schizophrenia. The present study examined the synaptic organization of the caudate and putamen in schizophrenia. Postmortem striatum was obtained from 10 normal controls (NC) and 17 subjects with schizophrenia (SZ), prepared for electron microscopy, and analyzed using stereological principles. The densities of total synapses, asymmetric synapses (characteristic of excitatory inputs), and asymmetric axospinous synapses (characteristic of cortical input) were higher in the caudate of the SZs vs. NCs. These changes were most profound in the off‐drug SZ cases and were also elevated in subjects on antipsychotic drugs (APDs). In comparison to NCs, there were no significant differences in the putamen of the SZ cohort as a whole group; however, there were more asymmetric axospinous synapses in the off‐drug subgroup. The increase in density of synapses in the SZs does not appear to be caused by antipsychotic medication and may represent failure of normal synaptic pruning or abnormal sprouting. Higher density of cortical‐type synapses in SZs vs. NCs may reflect adaptation of corticostriatal circuitry or hyperstimulation of striatal projection neurons. The abnormal synaptic organization could have several important and different downstream effects depending on the precise circuitry involved and may be related to limbic or cognitive dysfunction in schizophrenia. Synapse 56:185–197, 2005. © 2005 Wiley‐Liss, Inc.