Differentiation of Theta Visual Motion from Fourier Motion Requires LC16 and R18C12 Neurons in Drosophila.
Differentiation of Theta Visual Motion from Fourier Motion Requires LC16 and R18C12 Neurons in Drosophila.
复制标题
区分 Theta 视觉运动与傅里叶运动需要果蝇中的 LC16 和 R18C12 神经元。
DOI：
10.1016/j.isci.2020.101041
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发表时间：
2020
期刊：
影响因子：
5.8
通讯作者：
Zhu Yan
中科院分区：
文献类型：
--
作者：
Ji Xiaoxiao;Yuan Deliang;Wei Hongying;Cheng Yaxin;Wang Xinwei;Yang Jihua;Hu Pengbo;Gestrich Julia Yvonne;Liu Li;Zhu Yan
许多动物感知高阶视觉运动的特征，这些特征超出了在一阶运动中定义的亮度的时空相关性。虽然近年来已经了解了一阶运动检测的神经机制，但那些潜在的高阶运动感知仍然不清楚。在这里，我们建立了一个范例，以评估检测theta运动-一种高阶运动-在自由walkingDrosophila。使用这种范式的行为筛选确定了中枢脑中的两个神经元簇，命名为R18 C12，它们是感知θ运动所必需的，但不是一阶运动所必需的。此外，θ运动激活的R18 C12神经元在结构和功能上位于小叶、小叶柱状细胞LC 16中的视觉投射神经元的下游，其通过乙酰胆碱（ACh）和毒蕈碱乙酰胆碱受体（mAChRs）的相互作用激活R18 C12神经元。目前的研究提供了新的见解LC神经元和神经元机制的视觉信息处理在复杂的自然场景。
Many animals perceive features of higher-order visual motion that are beyond the spatiotemporal correlations of luminance defined in first-order motion. Although the neural mechanisms of first-order motion detection have become understood in recent years, those underlying higher-order motion perception remain unclear. Here, we established a paradigm to assess the detection of theta motion—a type of higher-order motion—in freely walkingDrosophila. Behavioral screening using this paradigm identified two clusters of neurons in the central brain, designated as R18C12, which were required for perception of theta motion but not for first-order motion. Furthermore, theta motion-activated R18C12 neurons were structurally and functionally located downstream of visual projection neurons in lobula, lobula columnar cells LC16, which activated R18C12 neurons via interactions of acetylcholine (ACh) and muscarinic acetylcholine receptors (mAChRs). The current study provides new insights into LC neurons and the neuronal mechanisms underlying visual information processing in complex natural scenes.