Chemical heterogeneity of the striosomal compartment in the human striatum
Chemical heterogeneity of the striosomal compartment in the human striatum
复制标题
人类纹状体纹状体区室的化学异质性
DOI：
--
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发表时间：
1999
期刊：
影响因子：
--
通讯作者：
A. Parent
中科院分区：
文献类型：
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作者：
L. Prensa;J. Giménez;A. Parent
应用组织化学和免疫组织化学技术，对正常人死后组织的纹状体区室的神经化学组织进行了分析。通过使用以下标志物描绘纹状体：乙酰胆碱酯酶（AChE）、脑啡肽（ENK）、P物质（SP）、钙结合蛋白-D28 k（CB）、小清蛋白（PV）、钙视网膜蛋白（CR）、边缘系统相关膜蛋白（LAMP）、胆碱乙酰转移酶（ChAT）、酪氨酸羟化酶（TH）和NADPH-黄递酶。纹状体边界之间进行了比较，所概述的每个标记物应用于相邻的部分，并特别注意可能的变化，在化学特征的纹状体沿着rostrocaudal程度。本研究的主要结果如下：1）纹状体区室由两个化学上不同的区域组成：核心区和外围区; 2）核心区基本上不含CB，且ENK和LAMP的染色强度低于外围区; 3）尽管纹状体基本上不含AChE，但核心区的AChE活性略高于外围区; 4）核心和外周区域PV染色较弱，SP染色较强; 5）ChAT-、CR-和NADPH-心肌黄酶阳性神经元优先分布在外周区域; 6）在头侧纹状体水平，纹状体基本上缺乏TH，而尾部则相反; 7）在尾部纹状体水平，纹状体外周区域CB和ChAT染色较强。这些结果表明，人类的纹状体显示出惊人的复杂和异质的化学结构。J. Comp.神经元413：603-618，1999.© 1999 Wiley利斯公司
The neurochemical organization of the striosomal compartment in the human striatum was analyzed by histochemical and immunohistochemical techniques applied to postmortem tissue from normal individuals. The striosomes were delineated by using the following markers: acetylcholinesterase (AChE), enkephalin (ENK), substance P (SP), calbindin‐D28k (CB), parvalbumin (PV), calretinin (CR), limbic system‐associated membrane protein (LAMP), choline acetyltransferase (ChAT), tyrosine hydroxylase (TH), and NADPH‐diaphorase. Comparisons were made between striosomal boundaries, as outlined by each marker applied on adjacent sections, and particular attention was paid to possible variations in the chemical features of striosomes along the rostrocaudal extent of the striatum. The main findings of this study are as follows: 1) the striosomal compartment is composed of two chemically distinct domains: a core and a peripheral region; 2) the core is largely devoid of CB and displays a less intense staining for ENK and LAMP than the peripheral region; 3) although striosomes are largely devoid of AChE, the activity of this enzyme is slightly higher in the core than in the peripheral region; 4) the core and peripheral regions are weakly stained for PV and intensely stained for SP; 5) ChAT‐, CR‐ and NADPH‐diaphorase‐positive neurons are preferentially distributed in the peripheral region; 6) at rostral striatal levels, striosomes are largely devoid of TH, whereas the inverse is true caudally; and 7) at caudal striatal levels, the peripheral region of striosomes is intensely stained for CB and ChAT. These results demonstrate that the striosomes in human display a strikingly complex and heterogeneous chemical architecture. J. Comp. Neurol. 413:603–618, 1999. © 1999 Wiley‐Liss, Inc.
DOI：
10.1073/pnas.85.15.5733
发表时间：
1988-08-01
影响因子：
11.1
作者：
REINER, A;ALBIN, RL;YOUNG, AB
通讯作者：
YOUNG, AB