INTRA-NEURONAL ALUMINUM ACCUMULATION IN AMYOTROPHIC LATERAL SCLEROSIS AND PARKINSONISM-DEMENTIA OF GUAM
INTRA-NEURONAL ALUMINUM ACCUMULATION IN AMYOTROPHIC LATERAL SCLEROSIS AND PARKINSONISM-DEMENTIA OF GUAM
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DOI：
10.1126/science.7112111
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发表时间：
1982-01-01
期刊：
影响因子：
56.9
通讯作者：
GIBBS, CJ
中科院分区：
文献类型：
--
作者：
PERL, DP;GAJDUSEK, DC;GIBBS, CJ
在关岛的饮用水和花园土壤样本中发现了高水平的铝和低水平的钙和镁。用扫描电子显微镜和能量色散X射线能谱分析了肌萎缩侧索硬化症和帕金森痴呆的关马查莫罗患者和神经学正常对照组海马索默S区(H1区)内含神经原纤维缠结(NFT)和无NFT神经元的元素含量。初步数据显示，无论潜在的神经学诊断如何，含NFT的海马神经元核区和核周细胞质中铝显著积聚。这些发现扩大了神经元内铝与NFT形成之间的联系，并支持环境因素与Chamorro人群中神经退行性变化有关的假说。
High levels of Al and low levels of Ca and Mg have been found in samples of drinking water and garden soil from Guam. Scanning electron microscopy with energy-dispersive X-ray spectrometry was used to analyze the elemental content of neurofibrillary tangle (NFT)-bearing and NFT-free neurons within the Sommer''s sector (H1 region) of the hippocampus in Guamanian Chamorros with amyotrophic lateral sclerosis and parkinsonism-dementia and in neurologically normal controls. Preliminary data indicated prominent accumulation of Al within the nuclear region and perikaryal cytoplasm of NFT-bearing hippocampal neurons, regardless of the underlying neurological diagnosis. These findings extended the association between intraneuronal Al and NFT formation and supported the hypothesis that environmental factors were related to the neurodegenerative changes seen in the Chamorro population.