Microvascular thrombosis: a serious and deadly pathologic process in multiple diseases.
Microvascular thrombosis: a serious and deadly pathologic process in multiple diseases.
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微血管血栓形成：多种疾病中严重且致命的病理过程。
DOI：
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发表时间：
2011
影响因子：
5.7
通讯作者：
H. Kwaan
中科院分区：
文献类型：
--
作者：
H. Kwaan
长期以来，我们对血栓形成发病机制的大部分了解都是基于对大血管的观察。然而，最近我们对微血管系统以及微循环闭塞如何影响疾病中各种器官功能的关注发生了转变。本文概述了小血管中的微血栓形成，并讨论了其发展的渐进阶段。最初的事件是由多种疾病触发的，随后是第二阶段，多个促成因素放大了这一过程，最后阶段是微血管闭塞和微血管血栓形成。结果是受影响的器官恢复或受伤。如果这个过程被普遍化，它通常会带来灾难性或致命的结果。我们目前对影响因素主要作用的了解导致了一个新的范式。仅限于潜在致病因素的单一目标的治疗方法（例如使用抗凝剂）是不够的，而且常常不成功。因此，应考虑同时管理所有影响因素。
Much of our understanding of the pathogenesis of thrombosis has long been based on observations made on large blood vessels. Nevertheless, there has been a recent shift in our attention to the microvasculature and to how microcirculatory occlusion affects function of various organs in diseases. This article provides an overview of microthrombosis in small blood vessels, with discussion of the progressive stages of its development. The initial event is triggered by a variety of diseases, followed by a second phase when multiple contributory factors amplify the process with the final phase of microvascular occlusion and microvascular thrombosis. The outcome is either recovery or injury to the affected organ. If the process is generalized, it is often associated with catastrophic or fatal outcomes. Our current knowledge of the major role of contributory factors leads to a new paradigm. A therapeutic approach limited to a single target of the underlying pathogenic factor, such as the use of anticoagulants, is insufficient and too often unsuccessful. Simultaneous management of all the contributory factors should therefore be considered.
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影响因子：
20.3
作者：
Mitra, D;Jaffe, EA;Laurence, J
通讯作者：
Laurence, J
影响因子：
4.2
作者：
DIETRICH, WD;ALONSO, O;HALLEY, M
通讯作者：
HALLEY, M
影响因子：
20.3
作者：
Heinen, Stefan;Hartmann, Andrea;Skerka, Christine
通讯作者：
Skerka, Christine
血栓性血小板减少性紫癜/散发性溶血性尿毒症综合征病理生理学中微血管内皮细胞的凋亡。
DOI：
--
发表时间：
1997
期刊：
Seminars in hematology.
影响因子：
--
作者：
Laurence,J;Mitra,D
通讯作者：
Mitra,D
影响因子：
3.6
作者：
Leung, Lawrence L. K.;Myles, Timothy;Nishimura, Toshihiko;Song, Jason J.;Robinson, William H.
通讯作者：
Robinson, William H.