Dopamine modulates the plasticity of mechanosensory responses in Caenorhabditis elegans
Dopamine modulates the plasticity of mechanosensory responses in Caenorhabditis elegans
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DOI：
10.1038/sj.emboj.7600057
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发表时间：
2004-01-28
期刊：
影响因子：
11.4
通讯作者：
Van Tol, HHM
中科院分区：
文献类型：
--
作者：
Sanyal, S;Wintle, RF;Van Tol, HHM
多巴胺调节的行为，包括信息加工和奖赏，都具有行为可塑性。这些行为的中断被认为是支持药物成瘾和精神病。多巴胺介导的行为的可塑性，例如，习惯化和敏化，在分子水平上还没有很好地理解。我们发现，在线虫秀丽隐杆线虫中，D1样多巴胺受体基因（DOP-1）调节机械感觉行为的可塑性，其中多巴胺以前没有牵连。dop-1突变体对非局部机械刺激表现出更快的适应性。这种表型通过引入该基因的野生型拷贝而得以拯救。dop-1基因在机械感觉神经元，特别是ALM和PLM神经元中表达。使用mec-7启动子在机械感觉神经元中选择性表达dop-1基因挽救dop-1突变动物的机械感觉缺陷。酪氨酸羟化酶缺陷型C.秀丽线虫突变体（CAT-2）也表现出这些特定的行为缺陷。这些观察结果为多巴胺信号调节C.优美的
Dopamine-modulated behaviors, including information processing and reward, are subject to behavioral plasticity. Disruption of these behaviors is thought to support drug addictions and psychoses. The plasticity of dopamine-mediated behaviors, for example, habituation and sensitization, are not well understood at the molecular level. We show that in the nematode Caenorhabditis elegans, a D1-like dopamine receptor gene (dop-1) modulates the plasticity of mechanosensory behaviors in which dopamine had not been implicated previously. A mutant of dop-1 displayed faster habituation to nonlocalized mechanical stimulation. This phenotype was rescued by the introduction of a wild-type copy of the gene. The dop-1 gene is expressed in mechanosensory neurons, particularly the ALM and PLM neurons. Selective expression of the dop-1 gene in mechanosensory neurons using the mec-7 promoter rescues the mechanosensory deficit in dop-1 mutant animals. The tyrosine hydroxylase-deficient C. elegans mutant (cat-2) also displays these specific behavioral deficits. These observations provide genetic evidence that dopamine signaling modulates behavioral plasticity in C. elegans.