Accuracy of clinical criteria for AD in the Honolulu-Asia Aging Study, a population-based study
Accuracy of clinical criteria for AD in the Honolulu-Asia Aging Study, a population-based study
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DOI：
10.1212/wnl.57.2.226
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发表时间：
2001-07-24
期刊：
影响因子：
9.9
通讯作者：
Markesbery, WR
中科院分区：
文献类型：
--
作者：
Petrovitch, H;White, LR;Markesbery, WR
目的：在一项以日裔美国男性为基础的人群研究中确定AD的诊断准确性。在主要转诊中心，超过80%的病例（主要是高加索人）经神经病理学证实为AD;然而，基于人群的研究和不同种族的研究中关于诊断准确性的信息有限。研究方法：1991年至1993年，有3,734名男性参加了檀香山-亚洲老龄化研究，2,603名男性参加了1994年至1996年的痴呆症检查。诊断基于已发表的标准。对临床数据不知情的神经病理学家量化了神经纤维缠结（NFT）和神经炎斑块（NP）。结果如下：在220例尸检受试者中，临床评价显示68例认知正常，73例中度，79例痴呆：20例AD，27例血管性痴呆，19例AD +其他，13例其他痴呆。在20例单纯AD患者中，新皮质NFT最大密度中位数为6.9/mm（2），新皮质NP密度中位数为8.0/mm（2）。其他组的相应密度为
Objective: To determine diagnostic accuracy for AD in a population-based study of Japanese-American men. AD is neuropathologically confirmed for more than 80% of cases at major referral centers (primarily Caucasians); however, information on diagnostic accuracy in population-based studies and studies of different ethnic groups is limited. Methods: There were 3,734 men who participated in the Honolulu-Asia Aging Study 1991 through 1993 dementia examination and 2,603 in the 1994 through 1996 examination. Diagnoses were based on published criteria. Neuropathologists blinded to clinical data quantified neurofibrillary tangles (NFT) and neuritic plaques (NP). Results: Of 220 autopsied subjects, clinical evaluation revealed 68 with normal cognition, 73 intermediate, and 79 with dementia: 20 AD, 27 vascular dementia, 19 AD + other, and 13 other dementia. Among 20 cases with pure AD, the median value for maximum neocortical NFT density was 6.9/mm(2) and for neocortical NP density was 8.0/mm(2). Corresponding densities for other groups were