Isolation and characterization of viruses related to the SARS coronavirus from animals in Southern China
Isolation and characterization of viruses related to the SARS coronavirus from animals in Southern China
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DOI：
10.1126/science.1087139
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发表时间：
2003-10-10
期刊：
影响因子：
56.9
通讯作者：
Poon, LLM
中科院分区：
文献类型：
--
作者：
Guan, Y;Zheng, BJ;Poon, LLM
一种新型冠状病毒（SCoV）是引起严重急性呼吸系统综合征（SARS）的病原。从中国广东活禽市场发现的喜马拉雅棕榈果子狸中分离出scov样病毒。在其他动物（包括一只浣熊，原yonoides）和在同一市场工作的人身上也发现了病毒感染的证据。所有动物分离株都保留在大多数人类分离株中未发现的29个核苷酸序列。在零售市场的小型野生活体哺乳动物中检测到scov样病毒，表明存在种间传播途径，尽管天然宿主尚不清楚。
A novel coronavirus (SCoV) is the etiological agent of severe acute respiratory syndrome (SARS). SCoV-like viruses were isolated from Himalayan palm civets found in a live-animal market in Guangdong, China. Evidence of virus infection was also detected in other animals ( including a raccoon dog, Nyctereutes procyonoides) and in humans working at the same market. All the animal isolates retain a 29-nucleotide sequence that is not found in most human isolates. The detection of SCoV-like viruses in small, live wild mammals in a retail market indicates a route of interspecies transmission, although the natural reservoir is not known.