Major histocompatibility complex-linked specificity of gamma delta receptor-bearing T lymphocytes.
Major histocompatibility complex-linked specificity of gamma delta receptor-bearing T lymphocytes.
复制标题
携带 γδ 受体的 T 淋巴细胞的主要组织相容性复合体相关特异性。
作者：
L. Matis;R. Cron;J. Bluestone
最近的几项研究已经确定了CD3(T3)+CD4-CD8-T淋巴细胞的一个独特的亚群，它表达一种CD3相关的异源二聚体，由T细胞受体(TCR)γ基因编码的蛋白质和第二种称为TCR Delta的糖蛋白组成(参考文献1-4)。在TCRα-β(α-β)出现之前的胎儿个体发育过程中，TCR-γβ在CD3+胸腺细胞上表达，在CD3+CD4-CD8-成人胸腺细胞上表达，在成人外周淋巴器官和外周血中CD3+细胞亚群(1-10%)上表达。表达TCRγ-Delta的T细胞可能代表着一种独特的成熟T细胞谱系，具有在受体介导的信号作用下增殖的能力，并表现出非主要组织相容性复合体(MHC)限制性的细胞溶解。要了解这个T细胞亚群的功能，关键是识别TCRGamma Delta识别的配体(S)。在这里，我们描述了一种同种异体反应性CD3+CD4-CD8-TCRγ-增量表达，TCRα-β阴性的T细胞株，它表现出MHC相关的增殖和细胞毒性识别特异性。我们的结果表明，表达TCR-Gamma Delta的T细胞具有自我非自身MHC识别能力，它们在分化过程中可以像表达TCRα-β的T细胞一样，经历MHC影响的选择。
Several recent studies have identified a distinct subset of CD3(T3)+CD4-CD8-T lymphocytes that express a CD3-associated heterodimer made up of the protein encoded by the T-cell receptor (TCR) gamma-gene and a second glycoprotein termed TCR delta (refs 1-4). TCR gamma delta is expressed on CD3+ thymocytes during fetal ontogeny before the appearance of TCR alpha-beta (alpha beta) (refs 5-7), on CD3+CD4-CD8- adult thymocytes, and on a subset (1-10%) of CD3+ cells in adult peripheral lymphoid organs and the peripheral blood. TCR gamma delta-expressing T cells probably represent a distinct mature T-cell lineage with the capacity to proliferate in response to receptor-mediated signals, and to display non-major histocompatibility complex (MHC)-restricted cytolysis. Critical to understanding the function of this T-cell subset is the identification of the ligand(s) recognized by TCR gamma delta. Here we describe an alloreactive CD3+CD4-CD8-TCR gamma delta-expressing, TCR alpha beta-negative, T-cell line that manifests MHC-linked recognition specificity for both proliferation and cytotoxicity. Our results suggest that T cells expressing TCR gamma delta are capable of self-non-self MHC discrimination and that they can undergo MHC-influenced selection during differentiation like TCR alpha beta-expressing T cells.