AMPHETAMINE, HALOPERIDOL, AND EXPERIENCE INTERACT TO AFFECT RATE OF RECOVERY AFTER MOTOR CORTEX INJURY
AMPHETAMINE, HALOPERIDOL, AND EXPERIENCE INTERACT TO AFFECT RATE OF RECOVERY AFTER MOTOR CORTEX INJURY
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DOI：
10.1126/science.7100929
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发表时间：
1982-01-01
期刊：
影响因子：
56.9
通讯作者：
LAW, WA
中科院分区：
文献类型：
--
作者：
FEENEY, DM;GONZALEZ, A;LAW, WA
单侧切除运动皮质并置于窄光束上的大鼠显示短暂的对侧轻瘫。损伤后24小时给予单剂量的d-苯丙胺可立即和持久地加速恢复。这种作用被阻断氟哌啶醇或通过抑制动物8小时后立即开始安非他明管理。损伤后24小时给予单剂量氟哌啶醇明显减慢恢复。这种影响也被抑制动物。
Rats subjected to unilateral ablation of the motor cortex and placed on a narrow beam displayed transient contralateral paresis. An immediate and enduring acceleration of recovery was produced by a single dose of d-amphetamine given 24 h after injury. This effect was blocked by haloperidol or by restraining the animals for 8 h beginning immediately after amphetamine administration. A single dose of haloperidol given 24 h after injury markedly slowed recovery. This effect was also blocked by restraining the animals.