Cryoablation of stellate ganglia and atrial arrhythmia in ambulatory dogs with pacing-induced heart failure.
Cryoablation of stellate ganglia and atrial arrhythmia in ambulatory dogs with pacing-induced heart failure.
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DOI：
10.1016/j.hrthm.2009.08.011
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发表时间：
2009-12
期刊：
影响因子：
5.5
通讯作者：
Chen, Peng-Sheng
中科院分区：
文献类型：
--
作者：
Ogawa, Masahiro;Tan, Alex Y.;Song, Juan;Kobayashi, Kenzaburo;Fishbein, Michael C.;Lin, Shien-Fong;Chen, Lan S.;Chen, Peng-Sheng
关键词：
本研究的目的是检验以下假设：在起搏引起的心力衰竭 (HF) 犬模型中，星状神经节消融可以降低房性心律失常的发生率。起搏诱发心力衰竭的走动犬的自主神经放电与房性心律失常（包括心动过缓和心动过速）之间存在关联。我们对 6 只狗（实验组）的左右星状神经节尾半部和 T2-4 胸交感神经节进行了冷冻消融。然后，我们使用植入的无线电发射器连续记录左上星状神经节神经活动（SGNA）、迷走神经活动（VNA）和心电图。基线记录两周后，使用快速右心室起搏（28±4天）诱发心力衰竭。对照组（N=6）接受相同的手术，但冷冻消融除外。实验组没有出现阵发性房性快速心律失常（PAT）发作（与对照组相比，P<0.0001）。诱导心衰后，冷冻消融显着（p=0.0097）将长时间（> 3 s）窦性停顿（PSP）发作次数从第 1 天的 5±6 次减少到 0 次，从第 7 天的 250 ± 424 次减少到 11±11 次，从 123 ± 206 次减少到第 14 天的 30±33 次。仅在实验组中，VNA 可能单独发生，而不伴随 SGNA。然而，这些孤立的 VNA 事件并没有导致 PSP。组织学研究证实了星状神经节尾半部的成功冷冻消融。我们的结论是，冷冻消融双侧星状神经节和 T2-T4 胸神经节可显着减少起搏诱发心力衰竭犬交感神经放电引起的 PAT 和 PSP 发作。
The purpose of the present study is to test the hypothesis that stellate ganglia ablation can reduce the incidences of atrial arrhythmias in a canine model of pacing-induced heart failure (HF). There is an association between autonomic nerve discharges and atrial arrhythmias (including both bradycardia and tachycardia) in ambulatory dogs with pacing-induced HF. We performed cryoablation of the caudal half of left and right stellate ganglia and T2–4 thoracic sympathetic ganglia in 6 dogs (Experimental Group). We then continuously recorded left upper stellate ganglia nerve activity (SGNA), vagal nerve activity (VNA) and electrocardiogram using an implanted radiotransmitter. After two weeks of baseline recording, rapid right ventricular pacing (28 ± 4 days) was used to induce HF. Control Group (N=6) underwent the same procedures except for cryoablation. The Experimental Group had no paroxysmal atrial tachyarrhythmia (PAT) episodes (P<0.0001 compared with Control). Cryoablation significantly (p=0.0097) reduced prolonged (> 3 s) sinus pause (PSP) episodes from 5±6 to 0 in day 1, from 250 ± 424 to 11±11 in day 7 and from 123 ± 206 to 30±33 in day 14 after induction of HF. In experimental group only, VNA may occur alone without concomitant SGNA. However, these isolated VNA episodes did not result in PSP. Histological studies confirmed successful cryoablation of the caudal half of the stellate ganglia. We conclude that cryoablation of bilateral stellate and T2–T4 thoracic ganglia significantly reduced PAT and PSP episodes induced by sympathetic discharges in dogs with pacing-induced HF.
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影响因子：
37.8
作者：
Joung B;Tang L;Maruyama M;Han S;Chen Z;Stucky M;Jones LR;Fishbein MC;Weiss JN;Chen PS;Lin SF
通讯作者：
Lin SF
影响因子：
20.1
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ZIESKE, H
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24
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通讯作者：
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37.8
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通讯作者：
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作者：
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