Hydrogen sulfide induces calcium waves in astrocytes
Hydrogen sulfide induces calcium waves in astrocytes
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DOI：
10.1096/fj.03-1052fje
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发表时间：
2004-01-01
期刊：
影响因子：
4.8
通讯作者：
Kimura, H
中科院分区：
文献类型：
--
作者：
Nagai, Y;Tsugane, M;Kimura, H
硫化氢（H2S）改变海马长时程增强（LTP），并作为一种神经调质发挥作用。在这里，我们表明，硫化氢增加细胞内钙离子和诱导钙波在原代培养的星形胶质细胞以及海马切片。H2S增加了Ca 2+的内流，并在较小程度上导致细胞内Ca 2+库的释放。Ca ~（2+）通道抑制剂La ~（3+）和Gd ~（3+）能有效地阻断神经元兴奋引起的Ca ~（2+）波以及对外源性H_2S的反应。这些观察结果表明，H2S诱导Ca 2+波传播到邻近的星形胶质细胞。
Hydrogen sulfide (H2S) modifies hippocampal long-term potentiation (LTP) and functions as a neuromodulator. Here, we show that H2S increases intracellular Ca2+ and induces Ca2+ waves in primary cultures of astrocytes as well as hippocampal slices. H2S increases the influx of Ca2+ and to a lesser extent causes the release from intracellular Ca2+ stores. Ca2+ waves induced by neuronal excitation as well as responses to exogenously applied H2S are potently blocked by La3+ and Gd3+, inhibitors of Ca2+ channels. These observations suggest that H2S induces Ca2+ waves that propagate to neighboring astrocytes.