Internalization into cancer cells of zwitterionic amino acid polymers <i>via</i> amino acid transporter recognition
Internalization into cancer cells of zwitterionic amino acid polymers <i>via</i> amino acid transporter recognition
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两性离子氨基酸聚合物<i>通过</i>氨基酸转运蛋白识别内化到癌细胞中
DOI：
10.1039/d1py01010g
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发表时间：
2021
影响因子：
4.6
通讯作者：
Fujii Shota
中科院分区：
文献类型：
--
作者：
Takano Shin;Sakurai Kazuo;Fujii Shota
我们合成了基于赖氨酸和苯丙氨酸的两性离子氨基酸聚合物（ZAP），并评估了它们对氨基酸转运蛋白（AAT）的识别能力，与正常细胞相比，AAT在癌细胞上过表达。该研究清楚地表明，ZAP通过AAT介导的内吞作用内化，由于其两性离子氨基酸性质而没有细胞毒性。
We synthesized lysine- and phenylalanine-based zwitterionic amino acid polymers (ZAPs) and evaluated their recognition capability for amino acid transporters (AATs), which are overexpressed on cancer cells as compared with normal cells. This study clearly demonstrates that ZAPs are internalized via AAT-mediated endocytosis with no cytotoxicity owing to their zwitterionic amino acid nature.