The YAP and TAZ transcription co-activators: key downstream effectors of the mammalian Hippo pathway.
The YAP and TAZ transcription co-activators: key downstream effectors of the mammalian Hippo pathway.
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DOI：
10.1016/j.semcdb.2012.05.004
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发表时间：
2012-09
影响因子：
7.3
通讯作者：
Guan, Kun-Liang
中科院分区：
文献类型：
--
作者：
Hong, Wanjin;Guan, Kun-Liang
Hippo信号通路最初由果蝇的遗传研究定义，用于调节组织生长和器官大小。该途径在哺乳动物中高度保守，并且Hippo途径的失调与人类癌症有关。虽然控制Hippo通路的确切细胞外信号目前尚不清楚，但令人信服的证据支持Hippo通路在细胞接触抑制中的关键作用，这是癌细胞中通常丢失的特性。许多分子，如梅林肿瘤抑制蛋白，已被确定为调节核心Hippo通路组分的活性。在下游起作用的是两个关键的转录共激活因子，雅普和TAZ，它们介导Hippo途径的主要基因调控和生物学功能。本文就雅普/TAZ及其果蝇同源物Yki的生理功能和分子调控进行综述。
The Hippo signaling pathway was initially defined by genetic studies in Drosophila to regulate tissue growth and organ size. This pathway is highly conserved in mammals and dysregulation of the Hippo pathway has been implicated in human cancer. Although the exact extracellular signal that controls the Hippo pathway is currently unknown, compelling evidence supports a critical role of the Hippo pathway in cell contact inhibition, which is a property commonly lost in cancer cells. Many molecules, such as the merlin tumor suppressor protein, have been identified as regulating the activity of the core Hippo pathway components. Acting downstream are two key transcription co-activators, YAP and TAZ, which mediate the major gene regulation and biological functions of the Hippo pathway. This article will focus on the physiological function and molecular regulation of YAP/TAZ and its Drosophila homolog Yki.
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影响因子：
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影响因子：
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作者：
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通讯作者：
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DOI：
10.1073/pnas.0605266104
发表时间：
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影响因子：
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