Determination of bisphenol A and related substitutes/analogues in human breast milk using gas chromatography-tandem mass spectrometry
Determination of bisphenol A and related substitutes/analogues in human breast milk using gas chromatography-tandem mass spectrometry
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DOI：
10.1007/s00216-015-8469-9
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发表时间：
2015-03-01
影响因子：
4.3
通讯作者：
Le Bizec, Bruno
中科院分区：
文献类型：
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作者：
Deceuninck, Yoann;Bichon, Emmanuelle;Le Bizec, Bruno
双酚 A (BPA) 是一种广泛用于生产聚碳酸酯和环氧树脂的工业化学品。 BPA 被认为是一种内分泌干扰化学品 (EDC)，受到现有或正在进行的限制性法规的影响，并且越来越多地被用作 BPA 替代品的其他类似物所取代。因此，针对 BPA 和新兴相关类似物的人类生物监测研究似乎需要记录 BPA 监管行动的效率，并推动针对 BPA 替代品的风险评估研究。特别是，人们越来越关注早期暴露后的后期影响，自然地将母乳确定为优先暴露评估的目标生物基质，重点关注孕妇、胎儿和/或新生儿等关键亚群。在此背景下，开发了一种基于气相色谱法和串联质谱法 (GC-MS/MS) 的准确、灵敏的分析方法，用于定量母乳样品中痕量水平的 18 种“BPA 类”化合物（
Bisphenol A (BPA) is an industrial chemical widely used in the production of polycarbonate and epoxy resins. Identified as an endocrine-disrupting chemical (EDC), BPA is a matter of existing or ongoing restrictive regulations and then is increasingly being replaced by other analogues used as BPA's substitutes. Human biomonitoring studies focusing on both BPA and emerging related analogues consequently appear as a requirement either for documenting the efficiency of regulatory actions toward BPA and for fuelling incoming risk assessment studies toward BPA's substitutes. In particular, the increasing concern about the late effects consecutive to early exposures naturally identify human breast milk as a target biological matrix of interest for priority exposure assessment focused on critical sub-populations such as pregnant women, fetuses, and/or newborns. In this context, an accurate and sensitive analytical method based on gas chromatography coupled to tandem mass spectrometry (GC-MS/MS) was developed for the quantification of 18 "BPA-like" compounds in breast milk samples at trace levels (